亚胺培南与西司他丁同时给予老年人后的药代动力学。
Pharmacokinetics of imipenem and cilastatin after their simultaneous administration to the elderly.
作者信息
Toon S, Hopkins K J, Garstang F M, Aarons L, Rowland M
出版信息
Br J Clin Pharmacol. 1987 Feb;23(2):143-9. doi: 10.1111/j.1365-2125.1987.tb03022.x.
Abstract
The pharmacokinetics of imipenem and cilastatin were studied in a group of six healthy elderly male volunteers following the combined intravenous administration of 500 mg imipenem and 500 mg cilastatin sodium as either single or multiple (6 hourly for 6 days) 20 min constant-rate infusions. The pharmacokinetics of both imipenem and cilastatin in the elderly were similar to those of young individuals with mild renal failure (Verpooten et al., 1984). There was no change in the pharmacokinetics of either species with time following multiple-dosing. Correlations existed between total clearance and the glomerular filtration-rate (51Cr-EDTA) for both imipenem and cilastatin.
摘要
在一组六名健康老年男性志愿者中，研究了亚胺培南和西司他丁的药代动力学。以单次或多次（每6小时一次，共6天）20分钟恒速输注的方式联合静脉给予500mg亚胺培南和500mg西司他丁钠。老年受试者中亚胺培南和西司他丁的药代动力学与轻度肾衰竭的年轻个体相似（Verpooten等人，1984年）。多次给药后，两种药物的药代动力学均未随时间发生变化。亚胺培南和西司他丁的总清除率与肾小球滤过率（51Cr-EDTA）之间均存在相关性。
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