Department of Internal Medicine, Kochi Prefectural Hata-Kenmin Hospital.
Department of Clinical Epidemiology, Kochi Medical School, Kochi University.
Acta Med Okayama. 2021;75(5):659-661. doi: 10.18926/AMO/62781.
A 77-year-old woman with no history of malignancy presented with anorexia and bilateral lower extremity weakness. Her consciousness level worsened daily, so we performed a lumbar puncture. Cerebrospinal fluid (CSF) analysis indicated meningitis, but three rounds of CSF cytology showed no malignant cells. The patient's carcinoembryonic antigen (CEA) level was highly elevated in CSF, but normal in serum. Through gadolinium-enhanced brain/spinal magnetic resonance imaging and gastrointestinal endoscopy, she was diagnosed with leptomeningeal carcinomatosis (LC) from gastric cancer. CEA level in CSF facilitated the diagnosis of LC from gastric cancer because there were no malignant cells on CSF cytology.
一位 77 岁的老年女性,无恶性肿瘤病史,表现为食欲不振和双侧下肢无力。她的意识水平每天都在恶化,因此我们进行了腰椎穿刺。脑脊液(CSF)分析提示脑膜炎,但三次 CSF 细胞学检查均未发现恶性细胞。患者的癌胚抗原(CEA)水平在 CSF 中明显升高,而在血清中正常。通过钆增强脑/脊髓磁共振成像和胃肠内窥镜检查,她被诊断为胃癌所致的脑膜癌病(LC)。CSF 中的 CEA 水平有助于从胃癌中诊断 LC,因为 CSF 细胞学检查中没有恶性细胞。