吉非替尼过量致横纹肌溶解症
Rhabdomyolysis Caused by Gefitinib Overdose.
机构信息
Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan.
出版信息
Intern Med. 2022 May 15;61(10):1577-1580. doi: 10.2169/internalmedicine.8168-21. Epub 2021 Oct 26.
Abstract
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are common therapeutic agents for EGFR mutation-positive advanced non-small-cell lung cancer. There has been no report of rhabdomyolysis caused by an overdose of EGFR-TKIs. We herein review the existing literature on the subject and report a rare case of rhabdomyolysis due to an overdose of gefitinib, an EGFR-TKI.
摘要
表皮生长因子受体（EGFR）酪氨酸激酶抑制剂（TKIs）是 EGFR 突变阳性晚期非小细胞肺癌的常用治疗药物。目前尚无 EGFR-TKI 过量导致横纹肌溶解的报道。本文复习了相关文献，并报告一例吉非替尼（EGFR-TKI）过量导致的横纹肌溶解症罕见病例。
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