神经丝轻链预测多系统萎缩的疾病严重程度和进展。
Neurofilament Light Chain Predicts Disease Severity and Progression in Multiple System Atrophy.
机构信息
Department of Neurology, Laboratory of Neurodegenerative Disorders, Rare Diseases Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Huaxi MR Research Center (HMRRC), Department of Radiology, Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, China.
出版信息
Mov Disord. 2022 Feb;37(2):421-426. doi: 10.1002/mds.28847. Epub 2021 Oct 31.
BACKGROUND
Neurofilament light chain (NFL), a potential biomarker of multiple system atrophy (MSA), has been reported in several studies.
OBJECTIVES
The objective of this study was to investigate whether plasma NFL levels are correlated with the progression of motor and cognition function in MSA.
METHODS
Patients with MSA were part of a prospective cohort study with assessments at baseline and after 1 year. Plasma NFL was quantified using ultrasensitive Simoa technology.
RESULTS
A total of 91 patients with MSA and 60 healthy controls (HCs) were enrolled. NFL levels increased from baseline to 1-year follow-up (P = 0.010). Baseline plasma NFL levels were significantly associated with motor severity and progression in patients with MSA (P < 0.05) but not with cognitive progression (P > 0.05).
CONCLUSIONS
Plasma NFL is a reliable biomarker for the disease severity of MSA and monitoring the progression of MSA, but not the progression of cognition. © 2021 International Parkinson and Movement Disorder Society.
背景
神经丝轻链（NFL）是多种系统萎缩（MSA）的潜在生物标志物，已在多项研究中得到报道。
目的
本研究旨在探讨血浆 NFL 水平是否与 MSA 运动和认知功能的进展相关。
方法
MSA 患者为前瞻性队列研究的一部分，在基线和 1 年后进行评估。使用超敏 Simoa 技术定量检测血浆 NFL。
结果
共纳入 91 例 MSA 患者和 60 例健康对照者（HCs）。NFL 水平从基线到 1 年随访时增加（P=0.010）。基线时血浆 NFL 水平与 MSA 患者的运动严重程度和进展显著相关（P<0.05），但与认知进展无关（P>0.05）。
结论
血浆 NFL 是 MSA 疾病严重程度和监测 MSA 进展的可靠生物标志物，但不能监测认知进展。© 2021 国际帕金森病和运动障碍学会。
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