Takahashi H, Okabayashi H, Suga K, Iyoda I, Matsuzawa M, Ikegaki I, Yoshimura M, Ijichi H
J Hypertens Suppl. 1986 Dec;4(6):S156-9.
The role of the calcium ion in central cardiovascular regulation was investigated by injecting a calcium channel blocker, diltiazem, intracerebroventricularly (i.c.v.) in urethane-anaesthetized, DOCA-salt hypertensive rats. This produced a fall in blood pressure and bradycardia with corresponding decreases in abdominal sympathetic nerve activity. However, a similar amount of diltiazem injected intravenously (i.v.) did not affect abdominal sympathetic nerve activity despite an accompanying vasodepression. The responses to i.v. injections of diltiazem were not different between the two groups; however, the magnitude of the blood pressure fall, bradycardia and sympathetic inhibition with i.c.v. injections was greater in the DOCA rats than in the sham-operated animals. These results suggest that diltiazem causes the central nervous system to decrease the sympathetic nerve outflow. The augmented central vasodepressor responses to diltiazem in DOCA-salt hypertensive rats may indicate that calcium metabolism in the central nervous system is disrupted and that this is of importance in the pathogenesis of DOCA-salt hypertension in rats.
通过向氨基甲酸乙酯麻醉的DOCA-盐高血压大鼠脑室内注射钙通道阻滞剂地尔硫䓬，研究了钙离子在中枢心血管调节中的作用。这导致血压下降和心动过缓，同时腹部交感神经活动相应降低。然而，静脉注射等量的地尔硫䓬，尽管伴有血管减压作用，但并未影响腹部交感神经活动。两组对静脉注射地尔硫䓬的反应无差异；然而，与假手术动物相比，DOCA大鼠脑室内注射地尔硫䓬后血压下降、心动过缓和交感神经抑制的程度更大。这些结果表明，地尔硫䓬可使中枢神经系统减少交感神经输出。DOCA-盐高血压大鼠对中枢血管减压药物地尔硫䓬的反应增强，可能表明中枢神经系统中的钙代谢受到破坏，这在大鼠DOCA-盐高血压的发病机制中具有重要意义。
