Synthesis, proteolytic stability, and evaluation of DOTA conjugated p160 peptide based radioconjugates: [Lu]Lu-DOTA-p160.

In this work, we describe the synthesis, stability, and preliminary biological evaluation of [Lu]Lu-DOTA-p160 peptide-based radiopharmaceuticals. Our findings highlight that all DOTA-p160-peptide radioconjugates exhibit favorable proteolytic and enzymatic stability with a prolonged half-life in human plasma and serum. Cell uptake studies carried out on MCF-7 cell line revealed saturable binding of the radioconjugates in the nanomolar range, thereby demonstrating their promising potential in the imaging and therapy of breast tumors.