类风湿关节炎中与JAK抑制剂治疗相关的肺结节：一例报告

Pulmonary nodules associated with JAK inhibitor therapy in rheumatoid arthritis: A case report.

作者信息

Pannell N, Joseph D, Ally M M T M, Bida N M, Tintinger G R

机构信息

Department of Internal Medicine, Faculty of Health Sciences, University of Pretoria, South Africa.

出版信息

Afr J Thorac Crit Care Med. 2021 Oct 4;27(3). doi: 10.7196/AJTCCM.2021.v27i3.116. eCollection 2021.

DOI:10.7196/AJTCCM.2021.v27i3.116

PMID:34761206

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8573811/

Abstract

Patients with rheumatoid arthritis (RA) may receive Janus kinase (JAK) inhibitors to achieve optimal control of their disease. We report a case of a patient who received a selective JAK1 inhibitor and subsequently developed multiple pulmonary nodules with cavitation. Biopsies confirmed the presence of cryptococcosis and the patient responded well to anti-fungal therapy.

摘要

类风湿关节炎（RA）患者可能会接受 Janus 激酶（JAK）抑制剂治疗，以实现对疾病的最佳控制。我们报告了一例接受选择性 JAK1 抑制剂治疗的患者，该患者随后出现了多个伴有空洞形成的肺结节。活检证实存在隐球菌病，患者对抗真菌治疗反应良好。