Péron Julien, Dagonneau Tristan, Conrad Anne, Pineau Fanny, Calattini Sara, Freyer Gilles, Perol David, Sajous Christophe, Heiblig Maël
Medical Oncology Department, Institut de Cancérologie des Hospices Civils de Lyon, 69002 Lyon, France.
Laboratoire de Biométrie et Biologie Evolutive, Equipe Biostatistique-Santé, CNRS UMR 5558, Université Claude Bernard Lyon 1, 69100 Villeurbanne, France.
Cancers (Basel). 2021 Oct 21;13(21):5283. doi: 10.3390/cancers13215283.
It has been suggested that cancer patients are at higher risk of contracting COVID-19 and at higher risk of developing a severe form of the disease and fatality. This study's objectives were to measure the excess risk of mortality and morbidity of patients with cancer among patients hospitalized for a SARS-CoV-2 infection, and to identify factors associated with the risk of death and morbidity among cancer patients. All first cancer patients hospitalized for COVID-19 in the two main hospitals of the Lyon area were included. These patients were matched based on age, gender, and comorbidities with non-cancer control patients. A total of 108 cancer patients and 193 control patients were included. The severity at admission and the symptoms were similar between the two groups. The risk of early death was higher among cancer patients, while the risk of intubation, number of days with oxygen, length of stay in ICU, and length of hospital stay were reduced. The main factors associated with early death among cancer patients was the severity of COVID-19 and the number of previous chemotherapy lines. The outcomes appear to be driven by the severity of the infection and therapeutic limitations decided at admission.
有人认为，癌症患者感染新冠病毒的风险更高，患上重症和死亡的风险也更高。本研究的目的是衡量因感染新冠病毒住院的患者中癌症患者的额外死亡和发病风险，并确定癌症患者死亡和发病风险的相关因素。纳入了里昂地区两家主要医院所有因新冠病毒住院的初诊癌症患者。这些患者根据年龄、性别和合并症与非癌症对照患者进行匹配。共纳入了108名癌症患者和193名对照患者。两组患者入院时的严重程度和症状相似。癌症患者早期死亡风险较高，而插管风险、吸氧天数、重症监护病房住院时长和住院总时长则较低。癌症患者早期死亡的主要相关因素是新冠病毒感染的严重程度和既往化疗疗程数。结果似乎是由感染的严重程度和入院时确定的治疗限制所驱动的。
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