评估记忆 B 细胞和 T 细胞在异源二次登革热感染中作用的数学模型。
A mathematical model to evaluate the role of memory B and T cells in heterologous secondary dengue infection.
机构信息
Institute of Mathematics, Statistics and Scientific Computing - University of Campinas, Campinas, SP, Brazil.
Institute of Mathematics, Statistics and Scientific Computing - University of Campinas, Campinas, SP, Brazil.
出版信息
J Theor Biol. 2022 Feb 7;534:110961. doi: 10.1016/j.jtbi.2021.110961. Epub 2021 Nov 11.
We propose a mathematical model to investigate the antibody-dependent enhancement (ADE) phenomenon during secondary dengue infection. The model consists of an ODE system that describes the interaction of the dengue virus with macrophages and memory B and T cell role during the infection. The qualitative model analysis is done in terms of memory B and T cell cloning parameters and the basic reproduction number R. In the absence of memory B and T cell cloning, if R<1 the dengue virus population extinguishes, while for R>1, it tends asymptotically to a positive equilibrium. However, when we consider the memory B cell cloning, it is possible to occur dengue infection even when R<1. Memory T cells have an essential role in eliminating the possibility of ADE occurrence when R<1.
我们提出了一个数学模型来研究二次登革热感染期间的抗体依赖性增强 (ADE) 现象。该模型由一个 ODE 系统组成，该系统描述了登革热病毒与巨噬细胞和记忆 B 和 T 细胞在感染过程中的相互作用。定性模型分析是根据记忆 B 和 T 细胞克隆参数和基本繁殖数 R 进行的。在没有记忆 B 和 T 细胞克隆的情况下，如果 R<1，则登革热病毒种群灭绝，而当 R>1 时，它趋于渐近到一个正平衡点。然而，当我们考虑记忆 B 细胞克隆时，即使 R<1，也有可能发生登革热感染。当 R<1 时，记忆 T 细胞在消除 ADE 发生的可能性方面起着至关重要的作用。
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