大麻素通过独特的脂质途径激活 TRPV1。

TRPV1 Activation by Anandamide via a Unique Lipid Pathway.

机构信息

Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina 27412, United States.

出版信息

J Chem Inf Model. 2021 Dec 27;61(12):5742-5746. doi: 10.1021/acs.jcim.1c00893. Epub 2021 Nov 15.

DOI:10.1021/acs.jcim.1c00893

PMID:34780173

Abstract

The capsaicin receptor, transient receptor potential vanilloid type 1 (TRPV1), is a polymodal channel that has been implicated in the perception of pain and can be modulated by a variety of cannabinoid ligands. Here we report TRPV1 channel activation by the endocannabinoid, anandamide (AEA), in a unique, peripheral binding site via extended MD simulations. These results aim to expand the understanding of TRPV1 and assist in the development of new TRPV1 modulators.

摘要

辣椒素受体，瞬时受体电位香草素 1 型（TRPV1），是一种多模态通道，与疼痛感知有关，并可被各种大麻素配体调节。在这里，我们通过扩展 MD 模拟报告了内源性大麻素，花生四烯酸乙醇胺（AEA）在独特的外周结合位点对 TRPV1 通道的激活。这些结果旨在扩大对 TRPV1 的理解，并有助于开发新的 TRPV1 调节剂。