Huang Ching-Wen, Yeh Po-Ting, Tsao Po-Nien, Chou Hung-Chieh, Chen Chien-Yi, Yen Ting-An, Huang Hsin-Chung, Lai Tso-Ting
From the Department of Ophthalmology (C.-W.H., P.-T.Y., T.-T.L.), National Taiwan University Hospital, Taipei, Taiwan.
Department of Pediatrics (P.-N.T., H.-C.C., C.-Y.C., T.-A.Y., H.-C.H.), National Taiwan University Hospital, Taipei, Taiwan; Research Center for Developmental Biology & Regenerative Medicine (P.-N.T.), National Taiwan University, Taipei, Taiwan.
Am J Ophthalmol. 2022 May;237:22-31. doi: 10.1016/j.ajo.2021.11.007. Epub 2021 Nov 13.
To validate the performance of Postnatal Growth and Retinopathy of Prematurity (G-ROP) screening criteria in a Taiwanese cohort.
Screening evaluation with retrospective data.
Premature infants who underwent retinopathy of prematurity (ROP) screening between January 2015 and April 2019 at a tertiary hospital were examined. Infants with known final ROP results and complete longitudinal weight records were included. G-ROP screening criteria, both original and simplified (G-ROP 180 g), were applied as the prediction model for type 1 ROP; sensitivity and specificity were analyzed. The reduction in the number of infants requiring ROP screening and the number of funduscopic examinations were calculated.
A total of 303 infants with documented ROP outcomes and complete weight gain records were examined. Of these, 103 infants developed ROP, of whom 29 developed type 1 ROP, whereas the other 200 did not develop ROP. For the detection of type 1 ROP, the sensitivity and specificity of the original G-ROP screening criteria were 96.6% and 42.3%, and 100% and 31%, for the simplified G-ROP 180 g model, respectively. The reduction in the number of infants requiring screening and funduscopic examinations was 32.6% and 33.5% for the original G-ROP criteria, and 28.1% and 23.2% for the G-ROP 180 g model, respectively.
Both the original G-ROP and G-ROP 180 g criteria attained high sensitivities in detecting type 1 ROP in the current Taiwanese cohort, with the G-ROP 180-g model outperforming the original one. Validation and modification may be required before applying G-ROP screening criteria to different populations.
验证产后生长与早产儿视网膜病变（G-ROP）筛查标准在台湾队列中的表现。
采用回顾性数据进行筛查评估。
对2015年1月至2019年4月在一家三级医院接受早产儿视网膜病变（ROP）筛查的早产儿进行检查。纳入已知最终ROP结果且有完整纵向体重记录的婴儿。将原始和简化的（G-ROP 180 g）G-ROP筛查标准用作1型ROP的预测模型；分析敏感性和特异性。计算需要进行ROP筛查的婴儿数量和眼底检查次数的减少情况。
共检查了303例有记录的ROP结果且有完整体重增加记录的婴儿。其中，103例婴儿发生了ROP，其中29例发生了1型ROP，而其他200例未发生ROP。对于1型ROP的检测，原始G-ROP筛查标准的敏感性和特异性分别为96.6%和42.3%，简化的G-ROP 180 g模型分别为100%和31%。原始G-ROP标准需要筛查的婴儿数量和眼底检查次数的减少分别为32.6%和33.5%，G-ROP 180 g模型分别为28.1%和23.2%。
原始G-ROP和G-ROP 180 g标准在当前台湾队列中检测1型ROP时均具有较高的敏感性，G-ROP 180 g模型优于原始模型。在将G-ROP筛查标准应用于不同人群之前，可能需要进行验证和修改。
