Center of Biomedical Research, Division of Molecular Synthesis & Drug Discovery, SGPGIMS Campus, Raebareli Road, Lucknow 226014, Uttar Pradesh, India.
Chem Commun (Camb). 2021 Dec 7;57(97):13059-13074. doi: 10.1039/d1cc05104k.
Over the past two decades, the C-H bond activation and functionalization reaction has been known as a prevailing method for the construction of carbon-carbon and carbon-heteroatom bonds using various transition metal catalysts. In this context, the iridium-catalyzed C-H bond activation and borylation reaction is one of the most valued methods. However, the major challenge in these borylation reactions is how to control the proximal () and distal ( and ) selectivity. Interestingly, while so many approaches are now available for the proximal selective borylation of arenes, borylation at the distal and or position of arenes remains still challenging. Only a few approaches have been reported so far in the literature employing iridium catalysis. In this feature article, we have demonstrated some of the recent discoveries from our laboratories for the proximal () and distal ( and ) selective borylation reactions. Moreover, some of the recent catalyst engineering discoveries for the selective proximal borylation reactions for a diverse class of substrates have also been discussed. The discussion part of several other pioneering reports is limited due to the lack of scope of this feature article.
在过去的二十年中，C-H 键的活化和功能化反应已被公认为使用各种过渡金属催化剂构建碳-碳和碳-杂原子键的主要方法。在这种情况下，铱催化的 C-H 键活化和硼化反应是最有价值的方法之一。然而，这些硼化反应的主要挑战是如何控制近位（）和远位（和）选择性。有趣的是，虽然目前有许多方法可用于芳烃的近位选择性硼化，但芳烃的远位和或位的硼化仍然具有挑战性。迄今为止，文献中仅报道了几种采用铱催化的方法。在这篇专题文章中，我们展示了我们实验室在近位（）和远位（和）选择性硼化反应方面的一些最新发现。此外，还讨论了一些最近在选择性近位硼化反应方面的催化剂工程发现，这些发现适用于各种不同的底物。由于篇幅限制，本文无法对其他一些开创性报道的讨论部分进行详细介绍。
