Ir-catalyzed proximal and distal C-H borylation of arenes.

Over the past two decades, the C-H bond activation and functionalization reaction has been known as a prevailing method for the construction of carbon-carbon and carbon-heteroatom bonds using various transition metal catalysts. In this context, the iridium-catalyzed C-H bond activation and borylation reaction is one of the most valued methods. However, the major challenge in these borylation reactions is how to control the proximal () and distal ( and ) selectivity. Interestingly, while so many approaches are now available for the proximal selective borylation of arenes, borylation at the distal and or position of arenes remains still challenging. Only a few approaches have been reported so far in the literature employing iridium catalysis. In this feature article, we have demonstrated some of the recent discoveries from our laboratories for the proximal () and distal ( and ) selective borylation reactions. Moreover, some of the recent catalyst engineering discoveries for the selective proximal borylation reactions for a diverse class of substrates have also been discussed. The discussion part of several other pioneering reports is limited due to the lack of scope of this feature article.