原发性抗磷脂综合征伴网状青斑与女性性别和中风相关，与甲状腺疾病呈负相关。

Primary Antiphospholipid Syndrome with Livedo Reticularis is Linked to Female Sex and Stroke and Negatively Associated with Thyroid Disease.

机构信息

Institute for Health Sciences, Federal University of Bahia, Salvador, BA, Brazil.

Unit of Rheumatology, Hospital Evangélico Mackenzie, Curitiba, P.R., Brazil.

出版信息

Curr Rheumatol Rev. 2022;18(4):352-356. doi: 10.2174/1573397117666211116111322.

DOI:10.2174/1573397117666211116111322

PMID:34784875

Abstract

AIMS

To study the clinical and laboratory findings between patients with primary Antiphospholipid Syndrome (pAPS) with and without LR.

BACKGROUND

Livedo Reticularis (LR) is a common manifestation of Antiphospholipid Syndrome (APS). Although no previous study evaluated patients with and without LR.

METHODS

A transversal study including 66 pAPS patients was performed. Demographical, anthropometric, medication use, antiphospholipid antibodies profile data were evaluated, and LR's clinical and laboratory features. Patients were subdivided into one of two groups: pAPS with LR and pAPS without LR.

RESULTS

Both groups were alike concerning demographics and anthropometrics. Interestingly, the frequency of stroke (28.5 vs. 7.5%, p=0.04), as well as of Sneddon's syndrome (100 vs. 30.0%, p<0.0001), were higher in pAPS with LR than the other group. Conversely, patients in the pAPS without LR group had more thyroidopathy than those in the pAPS with LR group (80% vs. 50% %, p=0.03).

CONCLUSION

Patients with pAPS and LR have more stroke and seem to be protected from thyroidopathy. Careful follow-up of these patients is therefore advised.

摘要

目的

研究原发性抗磷脂综合征（pAPS）伴和不伴网状青斑（LR）患者的临床和实验室发现。

背景

网状青斑（LR）是抗磷脂综合征（APS）的常见表现。尽管以前没有研究评估过有和没有 LR 的患者。

方法

进行了一项包括 66 例 pAPS 患者的横断面研究。评估了人口统计学、人体测量学、药物使用、抗磷脂抗体谱数据，以及 LR 的临床和实验室特征。患者被分为两组之一：pAPS 伴 LR 和 pAPS 不伴 LR。

结果

两组在人口统计学和人体测量学方面相似。有趣的是，pAPS 伴 LR 组的中风（28.5%比 7.5%，p=0.04）和 Sneddon 综合征（100%比 30.0%，p<0.0001）的频率更高。相反，pAPS 不伴 LR 组的甲状腺功能减退症患者比 pAPS 伴 LR 组更多（80%比 50%，p=0.03）。