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从... 中分离得到香豆素、黄酮类化合物和萜类化合物,并对其进行化学表征和抗炎活性研究。

Isolation, chemical characterization, and anti-inflammatory activity of coumarins, flavonoids, and terpenes from .

机构信息

Doctorado en Ciencias Biológicas y de la Salud, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana (UAM), México City, México.

Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social (IMSS), Xochitepec, Morelos, México.

出版信息

Nat Prod Res. 2022 Sep;36(18):4751-4756. doi: 10.1080/14786419.2021.2005592. Epub 2021 Nov 17.


DOI:10.1080/14786419.2021.2005592
PMID:34789033
Abstract

is widely used in traditional Mexican medicine for several disorders, including those associated with inflammation. In this work, fifteen compounds were identified (-) from . Some of these compounds (-, , -) were detected for the first time in the plant, and quercetagetin 7--β-(6''-Protocatecoyl) glucopyranoside () has been identified for any plant species. The inflammation inhibition effects of these compounds were as follows: Amix (-) > > > > > Bmix (-) > ; and showed a dose-response behavior. The mixture of and was not active. This work contributes to the knowledge of the anti-inflammatory capacity of and the chemical identity of their bioactive compounds.

摘要

被广泛应用于传统墨西哥医学,用于治疗多种疾病,包括与炎症相关的疾病。在这项工作中,从 中鉴定出了十五种化合物(-)。其中一些化合物(-、-、-)在该植物中首次被发现,并且槲皮素 7--β-(6''-原儿茶酰基)葡萄糖苷()被鉴定为任何植物物种。这些化合物的抗炎抑制作用如下:Amix(-)> > > > > Bmix(-)> ;和 表现出剂量反应行为。和 的混合物没有活性。这项工作有助于了解 的抗炎能力及其生物活性化合物的化学特征。

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引用本文的文献

[1]
Novel coumarin linked pyrazoles, thiazoles, and thiadiazoles: synthetic strategies and in vitro antimicrobial investigation.

Future Med Chem. 2025-1

[2]
Synergistic Interaction Effect of Artemisia cina n-hexane Extract and Tagetes lucida Ethyl Acetate Extract on Haemonchus Contortus.

Acta Parasitol. 2024-6

[3]
Effects of Five Coumarins and Standardized Extracts from Cav. on Motor Impairment and Neuroinflammation Induced with Cuprizone.

Pharmaceuticals (Basel). 2023-9-30

[4]
An Integrated Molecular Networking and Docking Approach to Characterize the Metabolome of and Its Pharmaceutical Potentials.

Metabolites. 2023-10-23

[5]
Synthesis and antimicrobial activity of new series of thiazoles, pyridines and pyrazoles based on coumarin moiety.

Sci Rep. 2023-6-19

[6]
Dose-Effect Determination of a Neuroprotector Fraction Standardized in Coumarins of and Bioavailability.

Pharmaceutics. 2023-3-17

[7]
Pharmacokinetics and Tissue Distribution of Coumarins from in an LPS-Induced Neuroinflammation Model.

Plants (Basel). 2022-10-22

[8]
Herniarin, Dimethylfraxetin and Extracts from , in Psychosis Secondary to Ketamine and Its Interaction with Haloperidol.

Plants (Basel). 2022-10-21

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