Al Awadhi Hamdan, Al Qassimi Sarah, Akhras Aya, Herlitz Leal, Ghosn Muriel
Division of Internal Medicine, Department of Medicine, Cleveland Clinic Abu Dhabi Hospital, Abu Dhabi, UAE.
Both authors contributed equally to this work.
Clin Nephrol Case Stud. 2021 Nov 9;9:123-129. doi: 10.5414/CNCS110711. eCollection 2021.
Bile acid nephropathy also known as cholemic nephropathy is a rare and overlooked form of acute kidney injury that occurs in the setting of severe hyperbilirubinemia. The exact etiology remains unknown, and there is a lack of treatment guidelines for this clinical condition. Anabolic steroids are known to cause hepatoxicity occasionally leading to acute kidney injury. We report the case of a 27-year-old male patient who developed bile acid nephropathy as a result of severe hyperbilirubinemia secondary to anabolic steroids-induced liver injury. He was conservatively managed. We review the current literature touching on the etiology, pathophysiology, diagnosis, and management of bile acid nephropathy in an attempt to shed light on this clinical condition, which may present as a diagnostic and therapeutic challenge.
胆汁酸肾病也称为胆血症肾病,是一种罕见且易被忽视的急性肾损伤形式,发生于严重高胆红素血症的情况下。确切病因尚不清楚,对于这种临床病症缺乏治疗指南。已知合成代谢类固醇偶尔会导致肝毒性,进而引发急性肾损伤。我们报告一例27岁男性患者,因合成代谢类固醇诱导的肝损伤继发严重高胆红素血症而发生胆汁酸肾病。他接受了保守治疗。我们回顾了当前关于胆汁酸肾病的病因、病理生理学、诊断和治疗的文献,试图阐明这种可能带来诊断和治疗挑战的临床病症。