Noah M L
Adv Prostaglandin Thromboxane Res. 1978;4:355-62.
Prostaglandin E1 was utilized for maintaining the patency of the ductus arteriosus in 19 infants with congenital lesions whose survival depended on ist patency. Fourteen of the patients had lesions which required blood flow from the aorta to the pulmonary artery (cyanotic group); 11 of these were considered successful. Two of the failures were in older infants aged 13 days and 1 month. The remaining five trials were in patients who required a flow of blood from pulmonary artery to aorta (left heart and aortic defect group), two of whom were considered to have responded successfully to the prostaglandin E1 administration. Based on this experience, it is suggested that this method of treatment is of benefit in the cyanotic group in providing emergency medical care while awaiting surgical palliation. A similar benefit in the aortic arch defect group would seem to be less well demonstrated at this time.
前列腺素E1被用于维持19例患有先天性病变婴儿的动脉导管通畅，这些婴儿的存活依赖于动脉导管的通畅。其中14例患者的病变需要血液从主动脉流向肺动脉（青紫组）；其中11例被认为是成功的。2例失败病例是13天和1个月大的较大婴儿。其余5例试验是在需要血液从肺动脉流向主动脉的患者（左心和主动脉缺损组）中进行的，其中2例被认为对前列腺素E1给药反应成功。基于这一经验，建议这种治疗方法在青紫组中有助于在等待手术姑息治疗时提供紧急医疗护理。目前，在主动脉弓缺损组中类似的益处似乎不太明显。
