磁共振波谱在肺部单发占位性病变鉴别诊断中的作用。
Role of magnetic resonance spectroscopy in differential diagnosis of solitary pulmonary lesions.
机构信息
Department of Radiology, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
出版信息
Diagn Interv Radiol. 2021 Nov;27(6):710-715. doi: 10.5152/dir.2021.20419.
PURPOSE
The aim of our study was to evaluate the availability of magnetic resonance spectroscopy (MRS) for the differentiation of benign or malignant pulmonary nodules and masses.
METHODS
A total of 59 patients (45 male, 14 female) with pulmonary nodules and masses were included in this prospective study. MRS was applied to the pulmonary lesions of the patients and choline levels were determined. Afterwards CT-guided percutaneous needle biopsy was performed. According to the biopsy results, pulmonary lesions were benign in 25 patients and malignant in 34 patients.
RESULTS
Choline levels were significantly higher in malignant lesions compared with benign lesions (p < 0.001). When the other conditions were kept constant, the probability of malignancy significantly increased by 17.38-fold (95% CI, 3.78-79.93) in those with choline levels >1.65 µmol/g compared to those with choline levels ≤1.65 µmol/g (p < 0.001).
CONCLUSION
MRS is a noninvasive method that can be used in the differential diagnosis of pulmonary nodules and masses.
目的
本研究旨在评估磁共振波谱（MRS）在区分良、恶性肺结节和肿块中的应用价值。
方法
本前瞻性研究共纳入 59 例（男 45 例，女 14 例）肺结节和肿块患者。对患者的肺部病变进行 MRS 分析并测定胆碱水平，然后进行 CT 引导下经皮穿刺活检。根据活检结果，25 例肺部病变为良性，34 例为恶性。
结果
恶性病变的胆碱水平明显高于良性病变（p<0.001）。在其他条件不变的情况下，胆碱水平>1.65µmol/g 者发生恶性肿瘤的概率明显高于胆碱水平≤1.65µmol/g 者（p<0.001），其恶性肿瘤的概率增加了 17.38 倍（95%CI，3.78-79.93）。
结论
MRS 是一种非侵入性方法，可用于肺结节和肿块的鉴别诊断。
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