M.D. Program in Internal Medicine, Department of Internal Medicine, School of Medicine, Federal University of Rio de Janeiro - UFRJ, Rua Professor Rodolpho Paulo Rocco, 255, 9º andar, sala 9E11, Ilha do Fundão, Rio de Janeiro, Rio de Janeiro, CEP: 21941-590, Brazil.
Dysphagia. 2022 Oct;37(5):1247-1257. doi: 10.1007/s00455-021-10380-7. Epub 2021 Nov 18.
Resistant arterial hypertension (RAH) is strongly associated with obstructive sleep apnea (OSA). Individuals with OSA may have subclinical swallow impairment, diagnosed by instrumental assessments, such as videofluoroscopy and fiberoptic endoscopic evaluation of swallowing (FEES). However, few studies have evaluated this population and included a control group of individuals without OSA. To evaluate, through FEES, the swallowing characteristics of resistant hypertensive patients with and without OSA and to investigate the association between the signs of swallow impairment and OSA. This was an observational study in which individuals with RAH underwent baseline polysomnography and were diagnosed with and without OSA. All participants underwent an initial assessment with the collection of demographic characteristics and FEES. Individuals were divided into 2 groups based on the presence or absence of OSA. Seventy-nine resistant hypertensive patients were evaluated: 60 with OSA (19 with mild OSA, 21 with moderate OSA, and 20 with severe OSA) and 19 without OSA. The most prevalent swallowing differences between groups with and without OSA were piecemeal deglutition, in 61.7% and 31.6%, respectively (p = 0.022); spillage, in 58.3% and 21.1% (p = 0.005); penetration/aspiration, in 55% and 47.4% (p = 0.561); and pharyngeal residue, in 51.5% and 26.3% (p = 0.053). The prevalence of swallow impairment among the participants in this study was 58.3% and 47.4% in the groups with OSA and without OSA, respectively (p = 0.402). This study shows a high prevalence of swallow impairment both in hypertensive patients with OSA and without OSA. The characteristics of swallowing associated with hypertensive patients with OSA are spillage, piecemeal deglutition, and the onset of the pharyngeal phase in the hypopharynx.
耐药性动脉高血压(RAH)与阻塞性睡眠呼吸暂停(OSA)密切相关。OSA 患者可能存在亚临床吞咽障碍,通过仪器评估(如荧光透视检查和纤维内镜吞咽功能评估[FEES])来诊断。然而,很少有研究评估过这一人群,并纳入了一组没有 OSA 的对照组。本研究通过 FEES 评估了伴有和不伴有 OSA 的耐药性高血压患者的吞咽特征,并探讨了吞咽障碍迹象与 OSA 之间的关联。这是一项观察性研究,纳入了 RAH 患者,对他们进行了基线多导睡眠图检查,并诊断为伴有或不伴有 OSA。所有参与者均接受了初始评估,收集了人口统计学特征和 FEES 数据。根据是否存在 OSA,将个体分为两组。共评估了 79 例耐药性高血压患者:60 例伴有 OSA(轻度 19 例,中度 21 例,重度 20 例)和 19 例不伴有 OSA。在伴有和不伴有 OSA 的两组之间,最常见的吞咽差异是分段吞咽,分别为 61.7%和 31.6%(p=0.022);溢漏,分别为 58.3%和 21.1%(p=0.005);渗透/吸入,分别为 55%和 47.4%(p=0.561);以及咽部残留物,分别为 51.5%和 26.3%(p=0.053)。在这项研究中,参与者中吞咽障碍的患病率在伴有 OSA 的组和不伴有 OSA 的组中分别为 58.3%和 47.4%(p=0.402)。本研究表明,伴有和不伴有 OSA 的高血压患者均存在较高的吞咽障碍患病率。与伴有 OSA 的高血压患者相关的吞咽特征是溢漏、分段吞咽和咽期在下咽部开始。