Bowling A T, Millon L, Hughes J P
Serology Laboratory, School of Veterinary Medicine, University of California, Davis 95616.
J Reprod Fertil Suppl. 1987;35:149-55.
Chromosomal abnormality was detectable in 98 of 180 mares aged 3 years or over with gonadal dysgenesis. The most common abnormality was X monosomy (63,X). The second most common abnormality was a karyotype indistinguishable by G- or C-banding from that of a male horse (64,XY). Two mares demonstrated structural abnormality of one X chromosome [64,X,del(Xp)] which has not previously been reported in horses. One of these foaled a filly with the same karyotype as her dam. Blood typing confirmed parentage of the foal. This is the only example in our experience of fertility in a mare with gonadal dysgenesis and chromosomal abnormality. Chromosomal abnormalities were also found in 4 yearling fillies investigated solely because of small size, poor conformation and lack of vigour. One was 63,X; one was 63,X/64,XX; one was 64X,del(Xp) and the 4th had an autosomal trisomy, tentatively 64,XX,i(?26), which demonstrated a second new abnormal karyotype of the horse.
在180匹3岁及以上患有性腺发育不全的母马中，有98匹检测到染色体异常。最常见的异常是X单体型（63,X）。第二常见的异常是其核型在G带或C带染色下与雄马无法区分（64,XY）。两匹母马表现出一条X染色体的结构异常[64,X,del(Xp)]，这在马中此前未见报道。其中一匹母马产下一匹与母本核型相同的雌驹。血型鉴定证实了这匹驹的亲子关系。这是我们所经历的患有性腺发育不全和染色体异常的母马具有生育能力的唯一例子。在4匹仅因体型小、体型不佳和活力不足而接受调查的一岁雌驹中也发现了染色体异常。一匹为63,X；一匹为63,X/64,XX；一匹为64X,del(Xp)，第四匹有常染色体三体，初步判定为64,XX,i(?26)，这展示了马的第二种新的异常核型。
