结缔组织病相关间质性肺疾病和肺动脉高压患者肺移植后的结局：一项回顾性队列研究。

Outcomes after lung transplantation among Chinese patients with connective tissue disease-associated interstitial lung disease and pulmonary hypertension: a retrospective cohort study.

机构信息

First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China.

Southern University of Science and Technology, Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen Institute of Respiratory Diseases, Shenzhen, China.

出版信息

Clin Exp Rheumatol. 2022 Sep;40(9):1666-1673. doi: 10.55563/clinexprheumatol/hld9sf. Epub 2021 Nov 3.

DOI:10.55563/clinexprheumatol/hld9sf

PMID:34796840

Abstract

OBJECTIVES

The present study aimed to compare the post-lung transplant survival and complications of connective tissue disease (CTD)-related interstitial lung disease (ILD) and/or pulmonary arterial hypertension with idiopathic pulmonary fibrosis (IPF).

METHODS

The clinical data of patients with CTD-ILD or IPF who received lung transplantation between 2015 and 2020 were retrospectively reviewed. Cumulative survival rates after transplantation were estimated using the Kaplan-Meier method.

RESULTS

The study included 31 patients with confirmed CTD-ILD and 98 with IPF. Patients with CTD-ILD were significantly younger (53.2 ± 13.7 vs. 62.3 ± 7.2 years, p=0.001) and more likely female (61.3% vs. 7.1%, p<0.001) than patients with IPF. No significant difference was noticed in the 1-year and 5-year survival rates between CTD-ILD and IPF patients (1-year, 73.2% vs 71.4%, p=0.76; 5-year, 69.1% vs. 39.5%, p=0.21). The incidence of primary graft dysfunction was significantly higher in CTD-ILD patients (90.3% vs. 70.4%, p=0.03), while there was no significant difference in primary graft dysfunction-related mortality (6.5% vs. 6.1%, p=0.95) between the two groups.

CONCLUSIONS

There was no significant difference in post-lung transplant survival and complications between CTD-ILD and IPF.

摘要

目的

本研究旨在比较结缔组织病（CTD）相关间质性肺疾病（ILD）和/或肺动脉高压与特发性肺纤维化（IPF）患者肺移植后的生存和并发症。

方法

回顾性分析了 2015 年至 2020 年间接受肺移植的 CTD-ILD 或 IPF 患者的临床资料。采用 Kaplan-Meier 法估计移植后累积生存率。

结果

本研究共纳入 31 例确诊为 CTD-ILD 和 98 例 IPF 患者。与 IPF 患者相比，CTD-ILD 患者明显更年轻（53.2±13.7 岁比 62.3±7.2 岁，p=0.001），且女性比例更高（61.3%比 7.1%，p<0.001）。CTD-ILD 和 IPF 患者的 1 年和 5 年生存率无显著差异（1 年：73.2%比 71.4%，p=0.76；5 年：69.1%比 39.5%，p=0.21）。CTD-ILD 患者原发性移植物功能障碍的发生率明显更高（90.3%比 70.4%，p=0.03），但两组原发性移植物功能障碍相关死亡率无显著差异（6.5%比 6.1%，p=0.95）。