Zhang Jun, He Xilin, Wan Yajie, Zhang Honghong, Tang Tao, Zhang Meng, Yu Shiyi, Zhao Weiyong, Chen Liming
School of Life Sciences, Nanjing Normal University, Nanjing, China.
Department of Oncology, Taizhou People's Hospital, Taizhou, Jiangsu, China.
Exp Hematol Oncol. 2021 Nov 19;10(1):54. doi: 10.1186/s40164-021-00247-w.
Hepatocellular carcinoma (HCC) is a common malignancy in human. CD44 is a transmembrane glycoprotein which is frequently overexpressed in cancer of various origins. The function and mechanism of CD44 in HCC remains elusive. In this study, we reported that CD44 was overexpressed in HCC to promote the proliferation and migration of HCC cells via oncogenic YAP, which is the key downstream regulator in Hippo pathway. These findings suggest that CD44-YAP is a probable important axis in pathogenesis of HCC, providing an insight in to HCC pathogenesis as well as potential targets for the intervention of HCC.
肝细胞癌（HCC）是人类常见的恶性肿瘤。CD44是一种跨膜糖蛋白，在各种起源的癌症中经常过度表达。CD44在HCC中的功能和机制仍不清楚。在本研究中，我们报道CD44在HCC中过度表达，通过致癌的YAP促进HCC细胞的增殖和迁移，YAP是Hippo通路中的关键下游调节因子。这些发现表明，CD44-YAP可能是HCC发病机制中的一个重要轴，为深入了解HCC发病机制以及HCC干预的潜在靶点提供了思路。
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