Kuo Y C, Lin C Y, Cheng S F, Lin C C, Liu W T
Graduate Institute of Microbiology and Immunology, National Yang-Ming Medical College, Taipei, Taiwan, Republic of China.
Cancer Detect Prev Suppl. 1987;1:51-5.
We investigated natural killer (NK) cytotoxicity in patients with recurrent herpes infection by using K562 cells infected with Herpes simplex virus type 1 (HSV-1) as target. The NK cytotoxicity was lower than during convalescence and in controls during recrudescence (0 to 3 days postonset of clinical symptoms; P less than 0.001). In the convalescent phase (4 to 14 days postonset of symptoms) the NK cytotoxicity was significantly higher than in controls (P less than 0.05). These results suggest that low NK cytotoxicity is related to the recurrence of herpes.
我们以感染了1型单纯疱疹病毒（HSV-1）的K562细胞为靶细胞，研究复发性疱疹感染患者的自然杀伤（NK）细胞毒性。在复发期（临床症状出现后0至3天），NK细胞毒性低于恢复期及对照组（P<0.001）。在恢复期（症状出现后4至14天），NK细胞毒性显著高于对照组（P<0.05）。这些结果表明，NK细胞毒性降低与疱疹复发有关。
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