通过序列荟萃分析得出，锰超氧化物歧化酶Ala16Val（rs4880）基因多态性与哮喘风险之间的联系并不显著。
Link between MnSOD Ala16Val (rs4880) polymorphism and asthma risk is insignificant from sequential meta-analysis.
作者信息
Alhobeira Hazza A, Mandal Raju K, Khan Saif, Dar Sajad A, Mahto Harishankar, Saeed Mohd, Wahid Mohd, Lohani Mohtashim, Khan Mahvish, Haque Shafiul
机构信息
Department of Restorative Dentistry, College of Dentistry, University of Ha'il, Ha'il-2440, Saudi Arabia.
Research and Scientific Studies Unit, College of Nursing & Allied Health Sciences, Jazan University, Jazan-45142, Saudi Arabia.
出版信息
Bioinformation. 2020 Nov 30;16(11):789-800. doi: 10.6026/97320630016789. eCollection 2020.
The mitochondrial manganese superoxide dismutase (MnSOD) enzyme protects lungs against oxidative stress by neutralizing the free radical superoxide produced in the respiratory function. This has relevance to asthma. Therefore, it is of interest to describe the potential effect of MnSOD Ala16Val genetic polymorphism to asthma risk. Known data in this context is inconclusive in nature. The possible link between MnSOD Ala16Val polymorphism and asthma is explored using sequence meta-analysis. Data from the pooled analysis of MnSOD Ala16Val polymorphism using five genetic models i.e., allelic (Val vs. Ala: p=0.846; OR=1.033, 95% CI=0.742 to 1.440) is discussed. Homozygous (Val Val vs. Ala Ala: p=0.517; OR=1.307, 95% CI=0.582 to 2.932) and heterozygous (Val Ala vs. Ala Ala: p=0.307; OR=1.138, 95% CI=0.888 to 1.459) data using the described models are documented. Data from the dominant model (Val Val + Val Ala vs. Ala Ala: p=0.301; OR=1.289, 95% CI=0.797 to 2.085) and the recessive model (Val Val vs. Val Ala + Ala Ala: p=0.761; OR=0.924, 95% CI=0.555 to 1.538) analyses for several ethnic subgroups in this context is reported.
线粒体锰超氧化物歧化酶（MnSOD）通过中和呼吸功能中产生的自由基超氧化物来保护肺部免受氧化应激。这与哮喘相关。因此，描述MnSOD Ala16Val基因多态性对哮喘风险的潜在影响很有意义。在这方面已知的数据本质上尚无定论。使用序列荟萃分析探索MnSOD Ala16Val多态性与哮喘之间的可能联系。讨论了使用五个遗传模型对MnSOD Ala16Val多态性进行汇总分析的数据，即等位基因模型（Val与Ala：p = 0.846；OR = 1.033，95% CI = 0.742至1.440）。记录了使用所述模型的纯合子（Val Val与Ala Ala：p = 0.517；OR = 1.307，95% CI = 0.582至2.932）和杂合子（Val Ala与Ala Ala：p = 0.307；OR = 1.138，95% CI = 0.888至1.459）数据。报告了在这方面对几个种族亚组进行显性模型（Val Val + Val Ala与Ala Ala：p = 0.301；OR = 1.289，95% CI = 0.797至2.085）和隐性模型（Val Val与Val Ala + Ala Ala：p = 0.761；OR = 0.924，95% CI = 0.555至1.538）分析的数据。
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