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印度一家三级护理中心提出的COVID-19相关鼻眶脑毛霉菌病分级系统及经验

A Proposed Grading System and Experience of COVID-19 Associated Rhino Orbito Cerebral Mucormycosis from an Indian Tertiary Care Center.

作者信息

Vaid Neelam, Mishra Prasun, Gokhale Nikhil, Vaid Sanjay, Vaze Varada, Kothadiya Ajay, Deka Trisha, Agarwal Rashmi

机构信息

Department of Otorhinolaryngology, KEM Hospital, Pune, Maharashtra India.

Department of Otorhinolaryngology, Bharati Vidyapeeth Medical College, Pune, Maharashtra India.

出版信息

Indian J Otolaryngol Head Neck Surg. 2022 Oct;74(Suppl 2):3505-3512. doi: 10.1007/s12070-021-02986-y. Epub 2021 Nov 15.

Abstract

Mucormycosis is an opportunistic fungal infection. India faced an unprecedented increase in patients with post coronavirus disease 2019 (COVID-19) associated rhino-orbito-cerebral mucormycosis (ROCM). This study proposes a grading system which correlates the extent of the disease with the management plan. An observational study was conducted January 2021-June 2021. We identified 65 patients. Eleven patients had mild disease, 27 patients had moderate, 16 patients were severe and 11 patients were graded as very severe. The management was planned based on this grading system. Early diagnosis, aggressive surgical debridement and antifungal drug therapy is the key to improve survival in ROCM. Procedures such as endoscopic orbital clearance, sublabial maxillectomy, and modified endoscopic Denkers (MED) approach facilitate access and surgical debridement. The new grading system proposed assists in planning the approach and extent of surgical debridement.

摘要

毛霉病是一种机会性真菌感染。印度面临2019冠状病毒病(COVID-19)相关鼻眶脑毛霉病(ROCM)患者数量前所未有的增加。本研究提出了一种分级系统,该系统将疾病程度与治疗方案相关联。于2021年1月至2021年6月进行了一项观察性研究。我们确定了65例患者。11例患者病情较轻,27例患者病情中等,16例患者病情严重,11例患者被评为非常严重。基于该分级系统制定了治疗方案。早期诊断、积极的手术清创和抗真菌药物治疗是提高ROCM患者生存率的关键。诸如内镜下眼眶清除术、唇下上颌骨切除术和改良内镜Denkers(MED)入路等手术有助于手术入路和清创。所提出的新分级系统有助于规划手术清创的入路和范围。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2cab/9702462/64d85a3dda87/12070_2021_2986_Fig1_HTML.jpg

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