Gaur Aaditya Vikram, Agarwal Rakhi
Laboratory of Analytical & Molecular Toxicology (Forensic Chemistry & Toxicology Laboratory), School of Forensic Science, National Forensic Sciences University, Sector 09, Gandhinagar 382007, Gujarat, India.
Forensic Science Laboratory, Kirumampakkam, Puducherry 607402, India.
Curr Res Toxicol. 2021 Oct 21;2:367-374. doi: 10.1016/j.crtox.2021.10.003. eCollection 2021.
Antipsychotic drugs (APDs) are prescribed for the treatment of psychiatric illness. However, these drugs can also contribute to several developmental and behavioral disorders. Contemporary studies to evaluate the toxic effects of numerous atypical antipsychotics are reported to cause behavioral alteration at variable doses in mammals and nematodes. Risperidone, the second most prescribed drug in India, requires more exploration of its adverse effects on humans. Here, we explore effects on feeding behavior and locomotion patterns due to risperidone exposure in model. The study targets to work out the toxic effects of risperidone exposure on feeding and locomotion behavior in addition to the expected pharmacological effects. N2 wild type strain was exposed in liquid culture assay for 2, 4, 6, 8, 10, and 12 hours with fixed 50 µM concentration. Feeding behavior was depleted due to inhibition in pharyngeal pumping varying from 11.05% - 45.67% in a time-dependent manner. Results of locomotion assay also show time-varying increase in reversals (4.9%-34.03%) and omega bends (26.23%-62.17%) with reduction in turn counts (29.07%- 42.2%) and peristaltic speed (31.38%-42.22%) amongst exposed groups as to control. The present work shows behavioral alterations due to risperidone exposure (50 µM) in is in a time-dependent manner. The study concludes that risperidone exposure in produces toxic effects with time, possibly caused by antagonizing other receptors apart from serotonin (5-H2T) and dopamine (D2) adding to its expected pharmacological effects.
抗精神病药物（APDs）被用于治疗精神疾病。然而，这些药物也可能导致多种发育和行为障碍。据报道，当代评估多种非典型抗精神病药物毒性作用的研究表明，它们在不同剂量下会导致哺乳动物和线虫的行为改变。利培酮是印度处方量第二大的药物，需要更多地探索其对人类的不良影响。在这里，我们探讨了利培酮暴露对模式生物的摄食行为和运动模式的影响。该研究旨在确定利培酮暴露除了预期的药理作用外，对摄食和运动行为的毒性作用。将N2野生型品系在液体培养试验中以固定的50µM浓度暴露2、4、6、8、10和12小时。由于咽部抽吸受到抑制，摄食行为减少，抑制程度在11.05% - 45.67%之间呈时间依赖性变化。运动试验结果还显示，与对照组相比，暴露组的反转次数（4.9% - 34.03%）和ω弯曲次数（26.23% - 62.17%）随时间增加，而转弯次数（29.07% - 42.2%）和蠕动速度（31.38% - 42.22%）减少。目前的研究表明，利培酮暴露（50µM）会导致模式生物的行为改变，且呈时间依赖性。该研究得出结论，利培酮暴露会随时间产生毒性作用，这可能是由于除了血清素（5 - H2T）和多巴胺（D2）受体外，还拮抗了其他受体，从而增加了其预期的药理作用。
