原发性颅内生殖细胞肿瘤的实用诊断方法及其治疗结果。

A pragmatic diagnostic approach to primary intracranial germ cell tumors and their treatment outcomes.

作者信息

Venkatasai Jeyaanth, Balakrishnan Rajesh, Rajkrishna Balakrishnan, Sebastain Patricia, John Rikki Rorima, Vanjare Harshad Arvind, Prabhu Krishna, Nair Bijesh, Mathew Leni Grace, Backianathan Selvamani

机构信息

Department of Radiation Oncology, Dr Ida B Scudder Cancer Center, Christian Medical College, Vellore, 632004, India.

Department of Radiation Oncology, Sri Ramachandra Institute of Higher Education and Research, Chennai, 600116, India.

出版信息

CNS Oncol. 2021 Nov 22;10(4):CNS79. doi: 10.2217/cns-2021-0012.

DOI:10.2217/cns-2021-0012

PMID:34806399

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8610002/

Abstract

Primary intracranial germ cell tumors (ICGCT) are often diagnosed with tumor markers and imaging, which may avoid the need for a biopsy. An intracranial germ cell tumor with mild elevation of markers is seldom stratified as a distinct entity. Fifty-nine patients were stratified into three groups: pure germinoma (PG), secreting germinoma (SG) and non-germinomatous germ cell tumors (NGGCTs). At 5 years, progression-free survival and overall survival of the three groups (PG vs SG vs NGGCT) were 91% versus 81% versus 59%, and 100% versus 82% versus 68%, respectively. There was no statistically significant difference in outcome among histologically and clinically diagnosed germinomas. A criterion for clinical diagnosis when a biopsy is not feasible is elucidated, and comparable outcomes were demonstrated with histologically diagnosed germinomas.

摘要

原发性颅内生殖细胞肿瘤（ICGCT）通常通过肿瘤标志物和影像学检查进行诊断，这可能避免活检的必要性。肿瘤标志物轻度升高的颅内生殖细胞肿瘤很少被分类为一个独特的实体。59例患者被分为三组：纯生殖细胞瘤（PG）、分泌性生殖细胞瘤（SG）和非生殖细胞性生殖细胞肿瘤（NGGCT）。5年时，三组（PG vs SG vs NGGCT）的无进展生存率和总生存率分别为91%对81%对59%，以及100%对82%对68%。组织学和临床诊断的生殖细胞瘤在预后方面无统计学显著差异。阐明了在活检不可行时的临床诊断标准，并证明其与组织学诊断的生殖细胞瘤具有相似的预后。