Wegener Alma, Kaagaard Molly D, Gomes Laura Cordeiro, Holm Anna Engell, Matos Luan O, Lima Karine O, Vieira Isabelle V M, de Souza Rodrigo Medeiros, Olsen Flemming Javier, Marinho Claudio Romero Farias, Biering-Sørensen Tor, Silvestre Odilson M, Brainin Philip
Multidisciplinary Center, Federal University of Acre, Câmpus Floresta, Cruzeiro do Sul, Acre, Brazil.
Cardiovascular Non-Invasive Imaging Research Laboratory, Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte, Hellerup, Denmark.
Int J Cardiovasc Imaging. 2022 Apr;38(4):813-822. doi: 10.1007/s10554-021-02475-x. Epub 2021 Nov 22.
Country- and ethnicity-specific reference values for echocardiographic parameters are necessary for decision making. No prior studies have examined reference values in adults from the Amazon Basin of Brazil. We performed echocardiographic examinations in 290 healthy adults (mean age 37 ± 14 years, 40% male) from the Brazilian Amazon. Left ventricular (LV) dimensions and volumes were obtained and indexed to body surface area. We also assessed systolic (LV ejection fraction [LVEF] and global longitudinal strain [GLS]) and diastolic function. LV dimensions and volumes were larger in males compared to females, but after indexation only volumes remained larger (P < 0.001 for all). Parameters of systolic function, were significantly greater in females (LVEF 50 to 68%, GLS - 17 to - 24%) than in males (LVEF 50 to 67%, GLS - 15 to - 23%, P < 0.05). Upper limits of normality for cardiac dimensions (indexed and non-indexed) were markedly higher compared to contemporary guidelines (American Society of Echocardiography) and the Brazilian subgroup in the World Alliance Society of Echocardiography (WASE). Lower limit of normality for LVEF (both sex 50%) and upper limit of normality for the left atrial volume index (LAVI) (male: 31 mL/m, female: 25 mL/m) were within normal range but slightly lower compared to guidelines and the WASE study. Other diastolic parameters, including E/A-ratio, E/e' ratio and peak tricuspid regurgitation velocity were compatible with present recommendations. Normal reference ranges of echocardiographic parameters in healthy adults from the Brazilian Amazon Basin may be different compared to international guidelines and data from other regions of Brazil. This applies specifically for LVEF and LAVI.
超声心动图参数的特定国家和种族参考值对于决策至关重要。此前尚无研究对巴西亚马逊盆地成年人的参考值进行过检查。我们对290名来自巴西亚马逊地区的健康成年人（平均年龄37±14岁，40%为男性）进行了超声心动图检查。获取左心室（LV）尺寸和容积并根据体表面积进行指数化。我们还评估了收缩功能（左心室射血分数[LVEF]和整体纵向应变[GLS]）和舒张功能。男性的左心室尺寸和容积大于女性，但指数化后仅容积仍较大（所有比较P<0.001）。女性的收缩功能参数（LVEF 50%至68%，GLS - 17%至 - 24%）显著高于男性（LVEF 50%至67%，GLS - 15%至 - 23%，P<0.05）。与当代指南（美国超声心动图学会）以及世界超声心动图联盟学会（WASE）中的巴西亚组相比，心脏尺寸（指数化和非指数化）的正常上限明显更高。LVEF的正常下限（两性均为50%）和左心房容积指数（LAVI）的正常上限（男性：31 mL/m²，女性：25 mL/m²）在正常范围内，但与指南和WASE研究相比略低。其他舒张参数，包括E/A比值、E/e'比值和三尖瓣反流峰值速度与当前建议相符。巴西亚马逊盆地健康成年人的超声心动图参数正常参考范围可能与国际指南以及巴西其他地区的数据不同。这尤其适用于LVEF和LAVI。
