代谢参数作为首发精神病的可能诊断预测指标：一项探索性回顾性队列研究。
Metabolic parameters as possible diagnostic predictors in first-episode psychosis: An exploratory retrospective cohort study.
机构信息
Early Intervention in Psychosis Unit, Psychiatry Department, Coimbra Hospital and Universitary Centre, Coimbra, Portugal.
Institute of Psychological Medicine, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
出版信息
Early Interv Psychiatry. 2022 Nov;16(11):1171-1174. doi: 10.1111/eip.13257. Epub 2021 Nov 22.
AIM
Patients in early phases of schizophrenia or mood disorders with psychotic symptoms have a wide array of metabolic abnormalities. We analysed the potential predictive value of uric acid (UA) levels and other metabolic parameters in first-episode psychosis patients to differentiate between non-affective and affective psychosis.
METHODS
Retrospective chart review of all patients referenced to a first-episode psychosis unit (n = 149), between 2012 and 2017, with available UA levels. Patients included (n = 37) were compared according to the follow-up diagnosis of schizophrenia or mood disorder.
RESULTS
Mood disorder patients presented higher UA levels (p = .030) and lower fasting blood glucose levels (p = .020) compared with schizophrenia patients. The remaining variables did not show significant intergroup differences.
CONCLUSIONS
Findings in this first-episode psychosis cohort support previous evidence suggesting higher UA levels as a predictor of affective psychosis and glucose dysfunction as predictive of schizophrenia. Further studies are needed to explore metabolic parameters as possible diagnostic predictors in first-episode psychosis.
目的
处于精神分裂症或伴有精神病性症状的心境障碍早期阶段的患者存在广泛的代谢异常。我们分析了首发精神病患者尿酸（UA）水平和其他代谢参数的潜在预测价值，以区分非情感性和情感性精神病。
方法
对 2012 年至 2017 年间入组首发精神病单元的所有患者（n=149）进行回顾性图表审查，这些患者均有 UA 水平数据。根据随访后的精神分裂症或心境障碍诊断对患者进行分组（n=37）。
结果
与精神分裂症患者相比，心境障碍患者的 UA 水平更高（p=0.030），空腹血糖水平更低（p=0.020）。其余变量在组间无显著差异。
结论
本首发精神病队列的研究结果支持之前的研究证据，即 UA 水平升高是情感性精神病的预测因素，葡萄糖功能障碍是精神分裂症的预测因素。需要进一步的研究来探索代谢参数作为首发精神病的可能诊断预测因子。
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