Meng D, Song L, Qi Z, Wang J, Liu H, Lyu Y J, Jia H X, Ding L, Hao M, Tian Z Q, Wang J T
Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan 030001, China.
Department of Obstetrics and Gynecology, Second Hospital of Shanxi Medical University, Taiyuan 030001, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2021 Jun 10;42(6):1103-1107. doi: 10.3760/cma.j.cn112338-20200829-01107.
To describe the characteristics of high-risk human papillomavirus (HR-HPV) infection and its influences by vaginal micro-environmental factors. A total of 421 women with HR-HPV infection and normal cervix diagnosed by pathology were selected from a community cohort established earlier by our research group for a 24-month follow-up. The baseline data were collected at enrollment. The vaginal micro-environmental factors were detected by using the combined detection kit of aerobic vaginitis and bacterial vaginosis. And the HPV was detected by using the flow-through hybridization technology. According to the HR-HPV infection status in baseline and 24 months of follow-up, with the prognosis characteristics of HR-HPV infection described, the impact of vaginal micro-environmental factors on the prognosis of HR-HPV infection was explored as well. Among 390 HR-HPV infected women who completed 24 months of follow-up, the top five types of persistent HR-HPV infection rate appeared as HPV16 (24.1%), HPV58 (22.2%), HPV53 (21.7%), HPV52 (20.0%), and HPV39 (11.8%), respectively. The results showed that women with abnormal vaginal pH (a=1.74, 95%: 1.08-2.80), abnormal neuraminidase (a=2.70, 95%: 1.52-4.83), or abnormal leucocyte esterase (a=3.41, 95%: 2.13-5.44), the risk of HR-HPV persistent infection increased. The abnormalities of neuraminidase and leukocyte esterase could increase the risk of persistent infection of homotype and heterotypic HR-HPV. HPV16 was prone to persistent infection. Abnormalities of vaginal pH, neuraminidase, and leukocyte esterase might increase the risk of HR-HPV persistent infection. Both the abnormalities of neuraminidase and leukocyte esterase play an essential role in the HR-HPV persistent infection.
描述高危型人乳头瘤病毒（HR-HPV）感染的特征及其受阴道微环境因素的影响。从本研究组早期建立的一个社区队列中选取421例经病理诊断为HR-HPV感染且宫颈正常的女性进行为期24个月的随访。在入组时收集基线数据。采用需氧性阴道炎和细菌性阴道病联合检测试剂盒检测阴道微环境因素。采用导流杂交技术检测HPV。根据基线和随访24个月时的HR-HPV感染状况，在描述HR-HPV感染预后特征的同时，探讨阴道微环境因素对HR-HPV感染预后的影响。在完成24个月随访的390例HR-HPV感染女性中，持续性HR-HPV感染率排名前五位的类型分别为HPV16（24.1%）、HPV58（22.2%）、HPV53（21.7%）、HPV52（20.0%）和HPV39（11.8%）。结果显示，阴道pH值异常（α=1.74，95%：1.08-2.80）、神经氨酸酶异常（α=2.70，95%：1.52-4.83）或白细胞酯酶异常（α=3.41，95%：2.13-5.44）的女性，HR-HPV持续感染风险增加。神经氨酸酶和白细胞酯酶异常可增加同型和异型HR-HPV持续感染风险。HPV16易于持续感染。阴道pH值、神经氨酸酶和白细胞酯酶异常可能增加HR-HPV持续感染风险。神经氨酸酶和白细胞酯酶异常在HR-HPV持续感染中均起重要作用。
