Straus Elizabeth, Worley Matthew J, Lyons Robert, Kline Alexander C, Tripp Jessica C, Davis Brittany C, Haller Moira, Angkaw Abigail C, Trim Ryan S, Norman Sonya B
VA San Diego Healthcare System, 3350 Villa La Jolla Drive, San Diego, CA 92161, USA; University of California, San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, CA 92037, USA.
James A. Haley Veteran's Hospital, 13000 Bruce B Downs Blvd, Tampa, FL 33612, USA; University of South Florida, 4202 E Fowler Ave, Tampa, FL 33620, USA.
J Anxiety Disord. 2022 Jan;85:102498. doi: 10.1016/j.janxdis.2021.102498. Epub 2021 Nov 14.
A substantial body of evidence supports the use of integrated treatments for posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD). Integrated trauma-focused exposure therapies reduce PTSD symptoms more than comparison treatments, including integrated coping skills therapies, but demonstrate lower attendance, raising questions regarding the relationships between attendance, outcomes, and treatment type. We aimed to examine these relationships in a RCT comparing integrated prolonged exposure (Concurrent Treatment for PTSD and Substance Use Disorders Using Prolonged Exposure, COPE; n = 58), to integrated coping skills therapy (Seeking Safety, SS; n = 52) offered in 12 sessions, with an option to extend up to four additional sessions. Participants were categorized based on number of sessions attended (0-4; 5-8; 9-12; 13-16). Multilevel modeling revealed that only when examining therapy attendance segments individually, clinical outcomes were comparable across treatments except in the 9-12 group, with COPE resulting in greater reductions in PTSD symptoms (p < 0.001), but not in alcohol use. Extending past 12 sessions was not associated with additional clinically meaningful symptom improvement for either treatment. These results suggest that attending a complete or near complete course of exposure therapy may enhance PTSD outcomes relative to non-trauma-focused therapies.
大量证据支持对创伤后应激障碍(PTSD)和酒精使用障碍(AUD)采用综合治疗。与包括综合应对技能疗法在内的对照治疗相比,综合创伤聚焦暴露疗法能更有效地减轻PTSD症状,但治疗出勤率较低,这引发了关于出勤率、治疗效果和治疗类型之间关系的疑问。我们旨在通过一项随机对照试验(RCT)来研究这些关系,该试验将综合延长暴露疗法(使用延长暴露疗法同时治疗PTSD和物质使用障碍,COPE;n = 58)与分12节提供且可选择额外延长4节的综合应对技能疗法(寻求安全,SS;n = 52)进行比较。参与者根据参加的节数进行分类(0 - 4节;5 - 8节;9 - 12节;13 - 16节)。多层次建模显示,只有在单独检查治疗出勤率分组时,除了9 - 12节组外,各治疗方法的临床疗效相当,COPE能更显著地减轻PTSD症状(p < 0.001),但对酒精使用情况的改善不明显。两种治疗方法超过12节后的延长治疗均未带来额外的具有临床意义的症状改善。这些结果表明,相对于非创伤聚焦疗法,参加完整或接近完整疗程的暴露疗法可能会改善PTSD的治疗效果。