Department of Radiology, Hematology and Clinical Oncology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil; Department of Neurosciences and Behavioral Sciences, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.
Department of Radiology, Hematology and Clinical Oncology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil; Department of Neurosciences and Behavioral Sciences, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.
Epilepsy Behav. 2021 Dec;125:108447. doi: 10.1016/j.yebeh.2021.108447. Epub 2021 Nov 25.
Cognitive functioning in epileptic syndromes has been widely explored in patients with temporal lobe epilepsy (TLE), but few studies have investigated the neuropsychological profile in posterior cortex epilepsy (PCE). In this study, we investigated the presurgical intellectual profile of children and adolescents with drug-resistant PCE.
Children and adolescents diagnosed with PCE (n = 25) participated in this study. The data were obtained from medical records, with assessments carried out between the years 2003 and 2019. To compare the intellectual profile, we also included patients diagnosed with frontal (n = 26) and temporal lobe epilepsy (n = 40). The Wechsler Intelligence Scales were used for the assessment of general intelligence.
There was an effect of the brain region on the Working Memory Index (p < 0.01), in which patients with TLE had significantly higher scores than groups with FLE (p < 0.01) and PCE (p < 0.05). We also demonstrated that patients with PCE tended to perform worse in the Processing Speed Index than patients with TLE (p = 0.055). The Full-Scale Intelligence Quotient, Verbal Comprehension, and Perceptual Reasoning indexes did not differ among the brain regions.
Children and adolescents with PCE demonstrated significant impairment in working memory and processing speed. The pattern of cognitive dysfunction in PCE was similar to that observed in FLE, which expands the evidence of the involvement of frontoparietal networks on cognitive proficiency.
颞叶癫痫（TLE）患者的认知功能已得到广泛研究，但很少有研究调查后部皮层癫痫（PCE）的神经心理学特征。在这项研究中，我们研究了耐药性 PCE 儿童和青少年的术前智力特征。
本研究纳入了 25 名被诊断为 PCE 的儿童和青少年。数据来自病历，评估时间为 2003 年至 2019 年。为了比较智力特征，我们还纳入了被诊断为额叶（n=26）和颞叶癫痫（n=40）的患者。韦氏智力测验用于评估一般智力。
大脑区域对工作记忆指数有影响（p<0.01），TLE 患者的得分明显高于 FLE 组（p<0.01）和 PCE 组（p<0.05）。我们还表明，PCE 患者的加工速度指数明显低于 TLE 患者（p=0.055）。全量表智商、言语理解和知觉推理指数在不同脑区之间无差异。
PCE 患儿的工作记忆和加工速度明显受损。PCE 的认知功能障碍模式与 FLE 相似，这进一步证明了额顶网络对认知能力的影响。
