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加泰罗尼亚新生儿转运中应用非伺服控制治疗性低温的挑战。

Challenges in the application of non-servocontrolled therapeutic hypothermia during neonatal transport in Catalonia.

机构信息

Neonatal and Paediatric Transport Unit. Sant Joan de Déu Hospital, Esplugues de Llobregat. Spain; Neonatal unit, Parc Taulí Hospital, Sabadell, Spain; Aerial Paediatric and Neonatal Transport Unit, Parc Taulí Hospital, Sabadell, Spain.

Neonatal and Paediatric Transport Unit. Sant Joan de Déu Hospital, Esplugues de Llobregat. Spain.

出版信息

An Pediatr (Engl Ed). 2021 Dec;95(6):459-466. doi: 10.1016/j.anpede.2021.07.005. Epub 2021 Nov 26.

Abstract

INTRODUCTION

Therapeutic hypothermia (TH) improves survival and neurological prognosis in hypoxic-ischemic encephalopathic (HIE) babies, being better the sooner TH is implemented. HIE babies are born more frequently in a non-cooling centre and need to be referred.

METHODS

Prospective-observational study (April 18 2018 - November 19 2019). Newborns (≥34 weeks of gestational age (GA) and >1800 g) with moderate/severe HIE on non-servocontrolled therapeutic hypothermia by the two neonatal transport teams in Catalonia.

RESULTS

51 newborns. The median stabilisation and transport time were 68 min (p25-75, 45-85 min) and 30 min (p25-75, 15-45 min), respectively. The mean age at arrival at the receiving unit was 4 h and 18 min (SD 96.6). The incubator was set off in 43 (84%), iced-packs 11 (21.5%) and both (11, 21.5%). Target temperature was reached in 19 (37.3%) babies. There were no differences in the overcooling in relation to the measures applied. The transport duration was not related with temperature stabilisation or target temperature reachiness.

CONCLUSIONS

Rectal temperature monitorisation is compulsory for the stabilisation and the application of non-servocontrolled hypothermia during transport. There is still time for improving in the administration of this treatment during transport. Servo-controlled hypothermia would be a better alternative to improve the management of HIE babies.

摘要

介绍

在患有缺氧缺血性脑病(HIE)的婴儿中,治疗性低温(TH)可提高生存率和神经预后,且实施 TH 的时间越早效果越好。患有 HIE 的婴儿通常在非降温中心出生,需要转院。

方法

前瞻性观察研究(2018 年 4 月 18 日至 2019 年 11 月 19 日)。有中度/重度 HIE 的新生儿(胎龄≥34 周,体重>1800g),由加泰罗尼亚的两个新生儿转运团队进行非伺服控制的治疗性低温治疗。

结果

共纳入 51 名新生儿。体温稳定和转运的中位时间分别为 68 分钟(p25-75,45-85 分钟)和 30 分钟(p25-75,15-45 分钟)。到达接收单位的平均年龄为 4 小时 18 分钟(标准差 96.6)。43 名(84%)新生儿使用了保温箱,11 名(21.5%)使用了冰袋,11 名(21.5%)同时使用了保温箱和冰袋。19 名(37.3%)婴儿达到了目标温度。所采用的措施与体温过低之间无差异。转运时间与体温稳定或达到目标温度无关。

结论

在转运过程中进行直肠温度监测对于稳定体温和实施非伺服控制低温是必要的。在转运过程中,仍有时间改进这种治疗方法的应用。伺服控制低温可能是改善 HIE 婴儿管理的更好选择。

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