Infectious Disease, The George Washington University Hospital, Washington, DC, USA
Infectious Disease, The George Washington University Hospital, Washington, DC, USA.
BMJ Case Rep. 2021 Dec 1;14(12):e245417. doi: 10.1136/bcr-2021-245417.
We present a case of polymicrobial subacute bacterial endocarditis and bacteremia with and in a 72-year-old man with pre-existing mitral valve disease and prior mitral valve repair who presented with renal failure and glomerulonephritis. is often a contaminant in blood cultures but has been rarely implicated in patients with invasive infections such as endocarditis. Intravenous drug use, prosthetic heart valves, valvular heart disease and venous catheters are the most frequently described risk factors for bacteremia and endocarditis in the medical literature. Management is challenging as is resistant to penicillin and cephalosporin antibiotics due to production of beta-lactamase. Polymicrobial endocarditis is uncommon and when it occurs typically involves species. To our knowledge, this is the first reported case of polymicrobial endocarditis in which both and a HACEK organism are implicated.
我们报告了一例 72 岁男性的多微生物亚急性细菌性心内膜炎和菌血症，该患者有先前存在的二尖瓣疾病和二尖瓣修复史，表现为肾衰竭和肾小球肾炎。在血液培养物中通常是一种污染物，但在患有侵袭性感染（如心内膜炎）的患者中很少涉及。静脉内药物使用、人工心脏瓣膜、瓣膜性心脏病和静脉导管是文献中最常描述的 菌血症和心内膜炎的危险因素。由于产生β-内酰胺酶， 对青霉素和头孢菌素类抗生素具有耐药性，因此治疗具有挑战性。多微生物心内膜炎并不常见，当发生时通常涉及 种微生物。据我们所知，这是首例报告的多微生物心内膜炎病例，其中涉及 和 HACEK 生物体。
