Ichikawa Masahiro, Yamakawa Tadashi, Sakamoto Rika, Takahashi Kenichiro, Suzuki Jun, Matsuura-Shinoda Minori, Shigematsu Erina, Tanaka Shunichi, Kaneshiro Mizuki, Asakura Taro, Kawata Takehiro, Yamada Yoshihiko, Nezu Osada Uru, Isozaki Tetsuo, Takahashi Atsushi, Kadonosono Kazuaki, Terauchi Yasuo
Department of Endocrinology and Diabetes, Yokohama City University Medical Center, Yokohama, Japan.
Kanazawa Medical Clinic, Yokohama, Japan.
Endocr J. 2022 Apr 28;69(4):399-406. doi: 10.1507/endocrj.EJ21-0408. Epub 2021 Nov 30.
This study aimed to reveal the relationship between quality of life (QOL) and sleep quality in patients with type 1 diabetes mellitus (T1DM). Overall, 202 patients with T1DM were registered in our study, and 192 were eligible for analysis. Baseline characteristics and laboratory values were determined. Patients completed the Japanese versions of the Pittsburgh Sleep Quality Index (PSQI) and Diabetes Therapy-Related QOL (DTR-QOL) questionnaires. We investigated the relationship between the global PSQI and DTR-QOL total scores by using linear regression analysis. In univariate regression analysis, DTR-QOL total scores were associated with body mass index, alcohol consumption, hypertension, hemoglobin A1c (HbA1c), and global PSQI score (all p-value <0.05) but not with sleep duration. When the association between PSQI subscales and DTR-QOL total scores was examined, DTR-QOL total scores were significantly related to subjective sleep quality and daytime dysfunction. In a multivariate regression analysis, the global PSQI score was negatively related to DTR-QOL total scores. Patients with an HbA1c concentration ≥8.0% had significantly lower DTR-QOL total scores. We revealed a relationship between QOL and sleep quality in T1DM patients and showed that the relationship between QOL and PSQI subscales in T1DM patients may be different from that in patients with type 2 diabetes mellitus. Assessing and managing sleep quality may be necessary for patients with diabetes to improve QOL.
本研究旨在揭示1型糖尿病（T1DM）患者的生活质量（QOL）与睡眠质量之间的关系。总体而言，202例T1DM患者登记参与我们的研究，其中192例符合分析条件。测定了基线特征和实验室值。患者完成了匹兹堡睡眠质量指数（PSQI）日语版和糖尿病治疗相关生活质量（DTR-QOL）问卷。我们通过线性回归分析研究了PSQI总体得分与DTR-QOL总分之间的关系。在单变量回归分析中，DTR-QOL总分与体重指数、饮酒、高血压、糖化血红蛋白（HbA1c）和PSQI总体得分相关（所有p值<0.05），但与睡眠时间无关。当检查PSQI各子量表与DTR-QOL总分之间的关联时，DTR-QOL总分与主观睡眠质量和日间功能障碍显著相关。在多变量回归分析中，PSQI总体得分与DTR-QOL总分呈负相关。HbA1c浓度≥8.0%的患者DTR-QOL总分显著较低。我们揭示了T1DM患者的生活质量与睡眠质量之间的关系，并表明T1DM患者生活质量与PSQI子量表之间的关系可能与2型糖尿病患者不同。评估和管理睡眠质量可能对糖尿病患者改善生活质量是必要的。
