Priesterbach Annique, Hommel Inge, van Nes Ilse
Sint Maartenskliniek, afd. Revalidatiegeneeskunde, Nijmegen.
Contact: Ilse van Nes (
Ned Tijdschr Geneeskd. 2021 Sep 30;165:D5820.
Depending on the level and severity of spinal cord injury (SCI), SCI patients may suffer from loss of autonomic nervous system function besides the well-known motor and sensory function loss. Changes in the autonomic control of the cardiovascular system can lead to the life-threatening phenomenon of autonomic dysreflexia (AD), especially in patients with cervical or high thoracic SCI. AD is defined as a sudden increase in systolic blood pressure of at least 20 mmHg above baseline. It results from an uncontrolled reaction of the sympathetic nervous system to a stimulus below the neurological SCI level. The characteristic symptoms above the neurological level are caused by vasodilation (headache, flushing, sweating, nasal congestion) whereas the symptoms below the neurological level are caused by vasoconstriction (piloerection). Recognition and appropriate management of AD are essential in preventing life-threatening complications of hypertensive crisis as well as identifying underlying disease requiring further treatment.
根据脊髓损伤(SCI)的程度和严重性,SCI患者除了众所周知的运动和感觉功能丧失外,还可能遭受自主神经系统功能丧失。心血管系统自主控制的变化可导致危及生命的自主神经反射异常(AD)现象,尤其是在颈髓或高位胸髓SCI患者中。AD被定义为收缩压突然升高至比基线至少高20 mmHg。它是由交感神经系统对神经SCI水平以下的刺激的不受控制的反应引起的。神经水平以上的特征性症状是由血管扩张引起的(头痛、脸红、出汗、鼻塞),而神经水平以下的症状是由血管收缩引起的(竖毛)。认识并适当处理AD对于预防高血压危象的危及生命的并发症以及识别需要进一步治疗的潜在疾病至关重要。