[Effect of cefodizime on the immune system: in vitro studies].

Cefodizime is a broad-spectrum cephalosporin with high efficacy, especially in experimental infections. The in vivo activity may be partly due to an immunomodulatory effect. Macrophages in cefodizime-treated mice showed enhanced activity (chemiluminescence, IL-1-synthesis, IFN-synthesis). The number of PFC increased during the treatment with cefodizime. The spleen cells of these mice showed elevated responses to dextransulfate and LPS but not to ConA or PHA.