Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China.
Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.
PLoS One. 2021 Dec 2;16(12):e0260479. doi: 10.1371/journal.pone.0260479. eCollection 2021.
It has been suggested that small intestinal bacterial overgrowth (SIBO) could cause nonalcoholic fatty liver disease (NAFLD), but this association was not examined in children by meta-analysis. This meta-analysis aimed to determine the association between SIBO and NAFLD in children. The electronic databases PubMed, Embase, and Cochrane Library were searched for studies published before April 22, 2021. The outcome was the association between SIBO and NAFLD. Three studies and 205 children were included. All three studies reported the association between SIBO and NAFLD. Children with SIBO were more likely to have NAFLD (odds ratio = 5.27, 95% confidence interval (CI): 1.66-16.68, P<0.001; I2 = 63.5%, Pheterogeneity = 0.065). When directly pooling the reported relative risks (RR) from two studies, children with NAFLD had an over 2-fold increased relative risk of developing SIBO (RR = 2.17, 05%CI: 1.66-2.82, P<0.001; I2 = 0.0%, Pheterogeneity = 0.837). This meta-analysis reports a possible association between SIBO and NAFLD in children.
有人提出小肠细菌过度生长（SIBO）可能导致非酒精性脂肪性肝病（NAFLD），但荟萃分析并未在儿童中检查这种关联。本荟萃分析旨在确定 SIBO 与儿童 NAFLD 之间的关系。检索了发表于 2021 年 4 月 22 日之前的电子数据库 PubMed、Embase 和 Cochrane Library 中的研究。结局是 SIBO 和 NAFLD 之间的关联。纳入了三项研究和 205 名儿童。三项研究均报道了 SIBO 和 NAFLD 之间的关联。患有 SIBO 的儿童更有可能患有 NAFLD（比值比=5.27，95%置信区间[CI]：1.66-16.68，P<0.001；I2=63.5%，P 异质性=0.065）。当直接汇总两项研究报告的相对风险（RR）时，患有 NAFLD 的儿童发生 SIBO 的相对风险增加了两倍多（RR=2.17，95%CI：1.66-2.82，P<0.001；I2=0.0%，P 异质性=0.837）。本荟萃分析报告了 SIBO 和儿童 NAFLD 之间可能存在的关联。
