Encoding histopathology whole slide images with location-aware graphs for diagnostically relevant regions retrieval.

Content-based histopathological image retrieval (CBHIR) has become popular in recent years in histopathological image analysis. CBHIR systems provide auxiliary diagnosis information for pathologists by searching for and returning regions that are contently similar to the region of interest (ROI) from a pre-established database. It is challenging and yet significant in clinical applications to retrieve diagnostically relevant regions from a database consisting of histopathological whole slide images (WSIs). In this paper, we propose a novel framework for regions retrieval from WSI database based on location-aware graphs and deep hash techniques. Compared to the present CBHIR framework, both structural information and global location information of ROIs in the WSI are preserved by graph convolution and self-attention operations, which makes the retrieval framework more sensitive to regions that are similar in tissue distribution. Moreover, benefited from the graph structure, the proposed framework has good scalability for both the size and shape variation of ROIs. It allows the pathologist to define query regions using free curves according to the appearance of tissue. Thirdly, the retrieval is achieved based on the hash technique, which ensures the framework is efficient and adequate for practical large-scale WSI database. The proposed method was evaluated on an in-house endometrium dataset with 2650 WSIs and the public ACDC-LungHP dataset. The experimental results have demonstrated that the proposed method achieved a mean average precision above 0.667 on the endometrium dataset and above 0.869 on the ACDC-LungHP dataset in the task of irregular region retrieval, which are superior to the state-of-the-art methods. The average retrieval time from a database containing 1855 WSIs is 0.752 ms. The source code is available at https://github.com/zhengyushan/lagenet.