骨髓微环境在急性髓系白血病中起什么作用？

What is the role of the bone marrow microenvironment in AML?

作者信息

Mulherkar Nirupama, Scadden David T

机构信息

Medical Writing Consultant, NM-INK, LLC, USA.

Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA; Harvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.

出版信息

Best Pract Res Clin Haematol. 2021 Dec;34(4):101328. doi: 10.1016/j.beha.2021.101328. Epub 2021 Oct 23.

DOI:10.1016/j.beha.2021.101328

PMID:34865700

Abstract

Acute myeloid leukemia (AML) continues to be associated with relapse and resistance to chemotherapy. The bone marrow microenvironment in AML has been shown to regulate responsiveness to chemotherapy and to support disease progression. This review summarizes some recent experimental insights into the crucial role of the bone marrow microenvironment in AML and persistence after chemotherapy.

摘要

急性髓系白血病（AML）仍然与复发及化疗耐药相关。AML中的骨髓微环境已被证明可调节对化疗的反应并支持疾病进展。本综述总结了近期关于骨髓微环境在AML及化疗后持续存在中的关键作用的一些实验性见解。