Weerasuriya A, Rapoport S I
Brain Res. 1986 Jun 4;375(1):150-6. doi: 10.1016/0006-8993(86)90967-4.
Using an in situ perfusion technique, we measured the [14C]sucrose permeability-surface area product (PA) in endoneurial capillaries of 48 frog sciatic nerves, as 6.6 +/- 0.6 (S.E.M.) X 10(-5) s-1, and the vascular space as 1.31 +/- 0.10%. Assuming A = 30 cm2/g, P = 2.2 X 10(-6) cm/s. P for sucrose was greater than P in some barrier tissues with tight junctions, but was less than P in all capillaries examined so far except rat cerebral capillaries. These observations demonstrate that endoneurial capillaries are an effective part of the blood-nerve barrier to water-soluble non-electrolytes. The findings are consistent with capillary impermeability to microperoxidase and with capillary ultrastructure.
采用原位灌注技术，我们测量了48条蛙坐骨神经神经内膜毛细血管中[14C]蔗糖的通透系数-表面积乘积（PA），为6.6±0.6（标准误）×10-5 s-1，血管空间为1.31±0.10%。假设A = 30 cm2/g，P = 2.2×10-6 cm/s。蔗糖的P值在一些具有紧密连接的屏障组织中大于P，但在迄今为止检查的所有毛细血管中，除大鼠脑毛细血管外，均小于P。这些观察结果表明，神经内膜毛细血管是血-神经屏障对水溶性非电解质的有效组成部分。这些发现与毛细血管对微过氧化物酶的不透性以及毛细血管超微结构一致。
