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卢旺达人遭受种族灭绝期间白细胞的甲基组印记：初步全基因组表观遗传学分析

Leukocyte methylomic imprints of exposure to the genocide against the Tutsi in Rwanda: a pilot epigenome-wide analysis.

机构信息

Centre for Human Genetics, College of Medicine & Health Sciences, University of Rwanda, Kigali, Rwanda.

Department of Clinical Psychology, College of Medicine & Health Sciences, University of Rwanda, Huye, Rwanda.

出版信息

Epigenomics. 2022 Jan;14(1):11-25. doi: 10.2217/epi-2021-0310. Epub 2021 Dec 8.

DOI:10.2217/epi-2021-0310
PMID:34875875
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8672329/
Abstract

We conducted a pilot epigenome-wide association study of women from Tutsi ethnicity exposed to the genocide while pregnant and their resulting offspring, and a comparison group of women who were pregnant at the time of the genocide but living outside of Rwanda. Fifty-nine leukocyte-derived DNA samples survived quality control: 33 mothers (20 exposed, 13 unexposed) and 26 offspring (16 exposed, 10 unexposed). Twenty-four significant differentially methylated regions (DMRs) were identified in mothers and 16 in children. genocide exposure was associated with CpGs in three of the 24 DMRs: ,  and , with higher DNA methylation in exposed versus unexposed offspring. Of note, and show significant correlation between brain and blood DNA methylation within individuals, suggesting these peripherally derived signals of genocide exposure may have relevance to the brain.

摘要

我们对在种族灭绝期间怀孕的图西族妇女及其后代进行了一项先导性全基因组关联研究，这些妇女的后代接触到了种族灭绝，同时还对在种族灭绝期间怀孕但居住在卢旺达境外的妇女进行了比较。有 59 个白细胞衍生的 DNA 样本通过了质量控制：33 位母亲（20 位暴露于种族灭绝，13 位未暴露）和 26 位后代（16 位暴露于种族灭绝，10 位未暴露）。在母亲中鉴定出 24 个差异甲基化区域（DMRs），在儿童中鉴定出 16 个 DMRs。种族灭绝暴露与三个 24 个 DMRs 中的 CpG 有关： 、 和 ，在暴露的后代中 DNA 甲基化水平高于未暴露的后代。值得注意的是， 和 显示出个体内大脑和血液 DNA 甲基化之间的显著相关性，这表明这些来自外围的种族灭绝暴露信号可能与大脑有关。