Seri Ahmed, Kamal Ali Mohamed Hala, Adam Essa Mohammed Elmujtba, Elagib Elnour Mohammed, Eltahirm Noha Ibrahim Ahmed, Mansour Salma Mohammed Alfatih, Ahmed Abdelkareem A
Department of Clinical Immunology, Royal Care International Hospital, Khartoum, Sudan.
Department of Immunology, Institute of Endemic Disease, University of Khartoum, Khartoum, Sudan.
Open Access Rheumatol. 2021 Nov 30;13:325-332. doi: 10.2147/OARRR.S339134. eCollection 2021.
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation of the synovial membrane. RA is classified as seropositive or seronegative, according to the absence or presence of primarily IgM RF, RF, and/or ACPA. The aim of this study is to identify the relationship between the serotype of rheumatoid arthritis and the level of ESR.
This is a descriptive, cross-sectional study done in Omdurman military hospital, Khartoum, Sudan. Conducted with 60 patients with RA, data were collected through a designated questionnaire which included demographic, age, gender, duration of the disease, laboratory finding. All the patients in the study were treated with conventional DMARDs and diagnosed according to the 2010 ACR/EULAR criteria; their disease activity status was assessed by DAS28/ESR. Data were analyzed using SPSS version 23.
The study found that 91.7% of the patients were females, patients of age group between 36 and 50 years had the highest percentage at 38.3% followed by those between 51 and 70 years and the least age group between 20 and 35 years, 36.7% and 15%, respectively. Of all the patients 61.7% were found to be SPRA, while the remaining 38.3% were seronegative (SNRA). Altogether 55% of the patients had moderate disease activity, followed by 16.7% who had a remission, 15% had high disease activity and the remaining 13.3% had low disease activity. The metacarpophalangeal (MCP) joint was found to be the only joint that was significantly associated with DAS28 and its involvement was greater among seropositive patients. The most affected joints were found to be shoulders, knees, wrist, MCP, PIP and elbow, in that order.
Females, middle-age group and shoulder joint were the most affected. Most RA was found to be SPRA, and the seropositive group was found to be more associated with high disease activity, while the seronegative group was associated with remission and low disease activity.
类风湿性关节炎（RA）是一种以滑膜炎症为特征的慢性自身免疫性疾病。根据主要IgM类风湿因子（RF）、RF和/或抗环瓜氨酸肽抗体（ACPA）的有无，RA可分为血清阳性或血清阴性。本研究的目的是确定类风湿性关节炎血清型与红细胞沉降率（ESR）水平之间的关系。
这是一项在苏丹喀土穆恩图曼军事医院进行的描述性横断面研究。对60例RA患者进行研究，通过一份指定问卷收集数据，问卷包括人口统计学、年龄、性别、病程、实验室检查结果。研究中的所有患者均接受传统改善病情抗风湿药（DMARDs）治疗，并根据2010年美国风湿病学会（ACR）/欧洲抗风湿病联盟（EULAR）标准进行诊断；采用疾病活动度评分28（DAS28）/ESR评估其疾病活动状态。使用SPSS 23版软件对数据进行分析。
研究发现91.7%的患者为女性，年龄在36至50岁之间的患者比例最高，为38.3%，其次是51至70岁的患者，年龄最小的20至35岁组患者比例分别为36.7%和15%。在所有患者中，61.7%被发现为血清阳性类风湿性关节炎（SPRA），其余38.3%为血清阴性（SNRA）。共有55%的患者疾病活动度为中度，其次是16.7%处于缓解期的患者，15%疾病活动度高，其余13.3%疾病活动度低。发现掌指关节（MCP）是唯一与DAS28显著相关的关节，且血清阳性患者中该关节受累更为严重。发现最常受累的关节依次为肩部、膝部、腕部、掌指关节、近端指间关节（PIP）和肘部。
女性、中年组和肩关节受累最为严重。发现大多数RA为SPRA，血清阳性组与高疾病活动度的相关性更强，而血清阴性组与缓解期及低疾病活动度相关。
Zotero 插件