Breast Cancer Surgery Division, European Institute of Oncology, IRCCS, Milan, 20141, Italy.
Departmentof Oncology & Hemato-Oncology, University of Milan, Milan, 20122, Italy.
Future Oncol. 2022 Jan;18(2):193-204. doi: 10.2217/fon-2021-0470. Epub 2021 Dec 9.
The clinical significance of nonvisualized sentinel lymph nodes (non-vSLNs) is unknown. The authors sought to determine the incidence of non-vSLNs on lymphoscintigraphy, the identification rate during surgery, factors associated with non-vSLNs and related axillary management. A total of 30,508 consecutive SLN procedures performed at a single institution from 2000 to 2017 were retrospectively studied. Associations between clinicopathological factors and the identification of SLNs during surgery were assessed. Non-vSLN occurred in 525 of the procedures (1.7%). In 73.3%, at least one SLN was identified intraoperatively. Nodal involvement was only significantly associated with SLN nonidentification (p < 0.001). Patients with non-vSLN had an increased risk for SLN metastasis. The detection rate during surgery was consistent, reducing the amount of unnecessary axillary dissection.
前哨淋巴结（SLN）未显影的临床意义尚不清楚。作者旨在确定淋巴闪烁显像术上未显影 SLN（non-vSLNs）的发生率、术中识别率、与 non-vSLNs 相关的因素及相关的腋窝管理。本研究回顾性分析了 2000 年至 2017 年在一家机构连续进行的 30508 例 SLN 手术。评估了临床病理因素与术中 SLN 识别之间的相关性。在 525 例手术中（1.7%）出现了 non-vSLN。73.3%的手术中至少识别到一个 SLN。淋巴结受累与 SLN 无法识别显著相关（p < 0.001）。non-vSLN 患者发生 SLN 转移的风险增加。术中检测率一致，减少了不必要的腋窝清扫。
Future Oncol. 2022-1
Cancer Biomark. 2018
Breast Cancer Res Treat. 2017-8-31
Diagnostics (Basel). 2024-1-24
Medicina (Kaunas). 2023-8-25
Zotero 插件