Lim Dong-Jin, Jang Insoo
Department of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL 35294-0012, USA.
Department of Internal Medicine, College of Korean Medicine, Woosuk University, Jeonju 54987, Korea.
Polymers (Basel). 2021 Nov 26;13(23):4131. doi: 10.3390/polym13234131.
In diabetes, lower extremity amputation (LEA) is an irreversible diabetic-related complication that easily occurs in patients with diabetic foot ulcers (DFUs). Because DFUs are a clinical outcome of different causes including peripheral hypoxia and diabetic foot infection (DFI), conventional wound dressing materials are often insufficient for supporting the normal wound healing potential in the ulcers. Advanced wound dressing development has recently focused on natural or biocompatible scaffolds or incorporating bioactive molecules. This review directs attention to the potential of oxygenation of diabetic wounds and highlights current fabrication techniques for oxygen-releasing composites and their medical applications. Based on different oxygen-releasable compounds such as liquid peroxides and solid peroxides, for example, a variety of oxygen-releasing composites have been fabricated and evaluated for medical applications. This review provides the challenges and limitations of utilizing current oxygen releasable compounds and provides perspectives on advancing oxygen releasing composites for diabetic-related wounds associated with DFUs.
在糖尿病中，下肢截肢（LEA）是一种不可逆的糖尿病相关并发症，很容易发生在患有糖尿病足溃疡（DFU）的患者身上。由于DFU是包括外周缺氧和糖尿病足感染（DFI）在内的不同病因的临床结果，传统的伤口敷料材料往往不足以支持溃疡中正常的伤口愈合潜能。先进伤口敷料的研发最近集中在天然或生物相容性支架或掺入生物活性分子上。本综述关注糖尿病伤口的氧合潜力，并强调当前用于制备释氧复合材料的技术及其医学应用。例如，基于不同的可释放氧的化合物，如液态过氧化物和固态过氧化物，已经制备了多种释氧复合材料并对其医学应用进行了评估。本综述阐述了利用当前可释放氧的化合物所面临的挑战和局限性，并对推进用于与DFU相关的糖尿病相关伤口的释氧复合材料提供了展望。
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