Laboratory for Molecular Psychosomatics, Department of Psychosomatic Medicine and Psychotherapy, University of Ulm, 89081 Ulm, Germany.
Department of Integrative Physiology, Center for Neuroscience and Center for Microbial Exploration, University of Colorado Boulder, Boulder, CO 80309, USA.
Int J Mol Sci. 2021 Nov 29;22(23):12938. doi: 10.3390/ijms222312938.
Inflammatory diseases and stressor-related psychiatric disorders, for which inflammation is a risk factor, are increasing in modern Western societies. Recent studies suggest that immunoregulatory approaches are a promising tool in reducing the risk of suffering from such disorders. Specifically, the environmental saprophyte National Collection of Type Cultures (NCTC) 11659 has recently gained attention for the prevention and treatment of stress-related psychiatric disorders. However, effective use requires a sophisticated understanding of the effects of NCTC 11659 and related rapidly growing mycobacteria (RGMs) on microbiome-gut-immune-brain interactions. This historical narrative review is intended as a first step in exploring these mechanisms and provides an overview of preclinical and clinical studies on NCTC 11659 and related RGMs. The overall objective of this review article is to increase the comprehension of, and interest in, the mechanisms through which NCTC 11659 and related RGMs promote stress resilience, with the intention of fostering novel clinical strategies for the prevention and treatment of stressor-related disorders.
在现代西方社会，炎症性疾病和与应激相关的精神障碍（炎症是其风险因素之一）的发病率正在上升。最近的研究表明，免疫调节方法是降低患此类疾病风险的有前途的工具。具体来说，环境腐生菌 国家典型培养物保藏中心（NCTC）11659 最近因其在预防和治疗与应激相关的精神障碍方面的作用而受到关注。然而，要有效利用它，就需要深入了解 NCTC 11659 及相关快速生长分枝杆菌（RGM）对微生物组-肠道-免疫-大脑相互作用的影响。本历史叙事性综述旨在作为探索这些机制的第一步，并概述了关于 NCTC 11659 和相关 RGM 的临床前和临床研究。本文的总体目标是提高对 NCTC 11659 和相关 RGM 促进应激弹性的机制的理解和兴趣，旨在为预防和治疗与应激相关的疾病提供新的临床策略。
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