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有机硒化合物对组蛋白去乙酰化酶抑制的影响及其在癌症治疗中的潜力。

The Effect of Organoselenium Compounds on Histone Deacetylase Inhibition and Their Potential for Cancer Therapy.

机构信息

Department of Medical Biochemistry, School of Laboratory Medicine and Medical Science, College of Health Sciences, Howard College Campus, University of KwaZulu-Natal, Durban 4041, South Africa.

出版信息

Int J Mol Sci. 2021 Nov 30;22(23):12952. doi: 10.3390/ijms222312952.

DOI:10.3390/ijms222312952
PMID:34884764
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8657714/
Abstract

Genetic and epigenetic changes alter gene expression, contributing to cancer. Epigenetic changes in cancer arise from alterations in DNA and histone modifications that lead to tumour suppressor gene silencing and the activation of oncogenes. The acetylation status of histones and non-histone proteins are determined by the histone deacetylases and histone acetyltransferases that control gene transcription. Organoselenium compounds have become promising contenders in cancer therapeutics. Apart from their anti-oxidative effects, several natural and synthetic organoselenium compounds and metabolites act as histone deacetylase inhibitors, which influence the acetylation status of histones and non-histone proteins, altering gene transcription. This review aims to summarise the effect of natural and synthetic organoselenium compounds on histone and non-histone protein acetylation/deacetylation in cancer therapy.

摘要

遗传和表观遗传变化改变了基因表达，导致癌症的发生。癌症中的表观遗传变化源于 DNA 和组蛋白修饰的改变，导致肿瘤抑制基因沉默和癌基因的激活。组蛋白和非组蛋白的乙酰化状态由组蛋白去乙酰化酶和组蛋白乙酰转移酶决定，它们控制基因转录。有机硒化合物已成为癌症治疗的有前途的候选药物。除了抗氧化作用外，几种天然和合成有机硒化合物和代谢物作为组蛋白去乙酰化酶抑制剂，影响组蛋白和非组蛋白的乙酰化状态，改变基因转录。本综述旨在总结天然和合成有机硒化合物对癌症治疗中组蛋白和非组蛋白乙酰化/去乙酰化的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18b4/8657714/192961bca1fa/ijms-22-12952-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18b4/8657714/a5f4589d2111/ijms-22-12952-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18b4/8657714/cf41b61741e1/ijms-22-12952-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18b4/8657714/0f77950828eb/ijms-22-12952-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18b4/8657714/34d446ca1af7/ijms-22-12952-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18b4/8657714/8ec96e225bef/ijms-22-12952-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18b4/8657714/192961bca1fa/ijms-22-12952-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18b4/8657714/a5f4589d2111/ijms-22-12952-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18b4/8657714/cf41b61741e1/ijms-22-12952-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18b4/8657714/0f77950828eb/ijms-22-12952-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18b4/8657714/34d446ca1af7/ijms-22-12952-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18b4/8657714/8ec96e225bef/ijms-22-12952-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18b4/8657714/192961bca1fa/ijms-22-12952-g006.jpg

相似文献

[1]
The Effect of Organoselenium Compounds on Histone Deacetylase Inhibition and Their Potential for Cancer Therapy.

Int J Mol Sci. 2021-11-30

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引用本文的文献

[1]
Preparturient Oral Selenitetriglycerides Supplementation Elevates Erythrocyte Glutathione Peroxidase Activity and Modulates Hepatic , , and mRNA in Postparturient Holstein-Friesian Cows.

Int J Mol Sci. 2025-8-19

[2]
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[3]
Seleno-Metabolites and Their Precursors: A New Dawn for Several Illnesses?

Metabolites. 2022-9-16

[4]
Unexpected kinetically controlled organoselenium-based isomaleimide: X-ray structure, hirshfeld surface analysis, 3D energy framework approach, and density functional theory calculation.

Front Chem. 2022-8-5

本文引用的文献

[1]
Hydroxamic Acid Derivatives: From Synthetic Strategies to Medicinal Chemistry Applications.

ACS Omega. 2021-8-20

[2]
Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics.

Adv Healthc Mater. 2021-8

[3]
Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives.

Nat Commun. 2021-5-24

[4]
[Roles of Gut Microflora in Selenium Metabolism of Host Animals].

Yakugaku Zasshi. 2021

[5]
Selenium in cereals: Insight into species of the element from total amount.

Compr Rev Food Sci Food Saf. 2021-5

[6]
Selenium-Based Novel Epigenetic Regulators Offer Effective Chemotherapeutic Alternative with Wider Safety Margins in Experimental Colorectal Cancer.

Biol Trace Elem Res. 2022-2

[7]
Selenium nanoparticles inhibit tumor metastasis in prostate cancer through upregulated miR-155-5p-related pathway.

Biosci Biotechnol Biochem. 2021-2-18

[8]
Biomedical Applications of Mycosynthesized Selenium Nanoparticles Using Penicillium expansum ATTC 36200.

Biol Trace Elem Res. 2021-10

[9]
Silencing of MEF2D by siRNA Loaded Selenium Nanoparticles for Ovarian Cancer Therapy.

Int J Nanomedicine. 2020-12-4

[10]
Selenium nanoparticles trigger alterations in ovarian cancer cell biomechanics.

Nanomedicine. 2020-10

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