西伯利亚虎（Panthera tigris altaica）皮肤无色素性扣带回黑色素瘤。

Cutaneous Amelanotic Signet-Ring Melanoma in a Siberian Tiger (Panthera tigris altaica).

机构信息

Texas A&M University, Department of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, College Station, Texas, USA.

出版信息

J Comp Pathol. 2021 Nov;189:141-144. doi: 10.1016/j.jcpa.2021.10.009. Epub 2021 Nov 26.

DOI:10.1016/j.jcpa.2021.10.009

PMID:34886982

Abstract

A 15-year-old male white Siberian tiger (Panthera tigris altaica) was evaluated for an elevated, ulcerated, cutaneous mass on the right flank. The mass was removed by excisional biopsy and submitted for histopathology. Based on distinct histological features of intracytoplasmic globular material and positive immunohistochemical staining for Melan-A and vimentin, an amelanotic signet-ring melanoma was diagnosed. While in domestic cats this neoplasm is associated with malignancy and a short survival time, the tiger had no local recurrence or related clinical disease approximately 4 years post surgery. Cutaneous melanocytic tumours are rare in big cats, and the findings in this case suggest that amelanotic signet-ring melanoma is not as malignant as its counterpart in domestic cats.

摘要

一只 15 岁的雄性白色西伯利亚虎（Panthera tigris altaica）因右肋部一个隆起、溃疡的皮肤肿块接受评估。该肿块通过切除活检切除，并进行组织病理学检查。基于细胞质内球形物质的独特组织学特征以及 Melan-A 和波形蛋白的阳性免疫组织化学染色，诊断为无色素性印戒细胞黑色素瘤。虽然在家猫中，这种肿瘤与恶性肿瘤和短的存活时间相关，但这只老虎在手术后大约 4 年没有局部复发或相关临床疾病。在大型猫科动物中，皮肤黑色素瘤很少见，本病例的结果表明，无色素性印戒细胞黑色素瘤并不像其在家猫中的对应物那样恶性。