Tartter P I, Martinelli G, Steinberg B, Barron D
Cancer Detect Prev. 1986;9(3-4):359-64.
Surgery for cancer in man is followed by immunosuppression, and immunosuppressed cancer patients have advanced stage and poor prognosis. Yet surgery continues to offer the best chance for cure for patients with solid tumors. Since natural-killer cells appear to play a major role in control of tumor metastases in experimental animals, we studied peripheral blood T-cell subsets and natural-killer cytotoxicity of 75 patients with colorectal cancer preoperatively and between 1 and 3 months postoperatively. There was no relationship between preoperative lymphocyte, T-cell, helper-cell, suppressor-cell, or natural-killer cell number or natural-killer cytotoxicity and stage of disease. One to 3 months following surgery natural-killer cells had increased more than 50% from 218 to 325 cells/cmm (T = 2.07, P = 0.0459). Natural killer cytotoxicity increased proportionally. Lymphocytes, T cells, suppressor cells, and helper cells increased insignificantly. The results suggest that potentially curative excision of solid tumors in man is eventually followed by return of immune function reflected by increased numbers of natural-killer cells.
人类癌症手术后会出现免疫抑制，而免疫抑制的癌症患者处于晚期且预后较差。然而，手术仍然为实体瘤患者提供了最佳的治愈机会。由于自然杀伤细胞似乎在实验动物的肿瘤转移控制中起主要作用，我们研究了75例结直肠癌患者术前及术后1至3个月外周血T细胞亚群和自然杀伤细胞的细胞毒性。术前淋巴细胞、T细胞、辅助细胞、抑制细胞或自然杀伤细胞数量以及自然杀伤细胞毒性与疾病分期之间没有关系。手术后1至3个月，自然杀伤细胞从218个/立方毫米增加到325个/立方毫米，增加了50%以上（T = 2.07，P = 0.0459）。自然杀伤细胞的细胞毒性成比例增加。淋巴细胞、T细胞、抑制细胞和辅助细胞增加不明显。结果表明，人类实体瘤的潜在治愈性切除最终会伴随着自然杀伤细胞数量增加所反映的免疫功能恢复。
