Bartocci A, Pollard J W, Stanley E R
J Exp Med. 1986 Sep 1;164(3):956-61. doi: 10.1084/jem.164.3.956.
Pregnancy results in an elevation in serum and tissue concentrations of the mononuclear phagocytic growth factor, CSF-1 (colony-stimulating factor 1). These increases are associated with an increase in the number of monocytes in the circulation, and with increases in the number of splenic macrophage precursors. In contrast to the approximately 2-fold elevation of the CSF-1 concentrations in serum and most tissues, pregnancy results in a 1,000-fold increase in the concentration of uterine CSF-1. The roughly fivefold elevation in uterine CSF-1 concentration observed at day 5 of pregnancy could be mimicked by administration of chorionic gonadotrophin in intact but not ovariectomized mice. These dramatic changes in uterine CSF-1 concentrations may indicate a role for CSF-1 in the regulation of nonmononuclear phagocytic cell types.
怀孕会导致血清和组织中单核吞噬细胞生长因子CSF-1（集落刺激因子1）的浓度升高。这些升高与循环中单核细胞数量的增加以及脾脏巨噬细胞前体数量的增加有关。与血清和大多数组织中CSF-1浓度大约升高2倍形成对比的是，怀孕会导致子宫CSF-1浓度增加1000倍。在怀孕第5天观察到的子宫CSF-1浓度大约升高5倍的情况，在完整但未切除卵巢的小鼠中，可通过注射绒毛膜促性腺激素来模拟。子宫CSF-1浓度的这些显著变化可能表明CSF-1在调节非单核吞噬细胞类型中发挥作用。
