Traditional Chinese Medicine Hospital of Guangdong Province, Guangzhou, China.
Shanxi Province Hospital of Traditional Chinese Medicine, Taiyuan, China.
Acupunct Med. 2022 Aug;40(4):289-298. doi: 10.1177/09645284211056655. Epub 2021 Dec 13.
To evaluate the efficacy/effectiveness and safety of acupuncture for the treatment of hot flushes and its impact on serum hormone levels in menopausal women.
A total of 10 databases were searched from their inception to August 2018. Reference lists of reviews and included articles were also hand-searched. Randomized controlled trials (RCTs) comparing the effect of acupuncture versus sham acupuncture, or acupuncture versus hormone therapy (HT), as treatment for menopausal hot flushes were included. Outcomes included hot flush frequency, hot flush severity and serum hormone levels of estradiol (E2), luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Meta-analyses were performed using Review Manager 5.3 software.
Thirteen RCTs including 1784 patients were selected, seven of which were available for meta-analysis. Compared with sham acupuncture, acupuncture significantly decreased hot flush frequency (mean difference (MD) -0.84, 95% confidence interval (CI) [-1.64, -0.05], I = 54%) from baseline to the end of study, but did not impact end scores of hot flush frequency (MD 0.19, 95% CI [-0.61, 0.99], I = 0%) or severity (MD 0.02, 95% CI [-0.13, 0.17], I = 0%). No differences were found between acupuncture and HT in serum levels of E (MD 6.56, 95% CI [-3.77, 16.89], I = 76%), FSH (MD 1.06, 95% CI [-1.44, 3.56], I = 0%) or LH (MD -3.36, 95% CI [-13.37, 6.65], I = 89%).
Acupuncture may not decrease hot flush frequency, but yet appears to have similar effects on serum hormone levels as HT, that is, increased E2 and decreased FSH and LH. Considering that no firm conclusions could be drawn due to the low quality and limited number of included trials included, further high-quality RCTs need to be conducted.
评价针灸治疗潮热的疗效和安全性，以及对绝经后妇女血清激素水平的影响。
检索了 10 个数据库，从建库到 2018 年 8 月。还手动检索了综述和纳入文章的参考文献列表。纳入了比较针灸与假针灸、或针灸与激素治疗（HT）治疗绝经后潮热效果的随机对照试验（RCT）。结局指标包括潮热频率、潮热严重程度和雌二醇（E2）、黄体生成素（LH）和卵泡刺激素（FSH）的血清激素水平。使用 Review Manager 5.3 软件进行荟萃分析。
共纳入 13 项 RCT，包括 1784 名患者，其中 7 项可进行荟萃分析。与假针灸相比，针灸从基线到研究结束时显著降低了潮热频率（均数差（MD）-0.84，95%置信区间（CI）[-1.64，-0.05]，I = 54%），但对潮热频率的最终评分（MD 0.19，95%CI[-0.61，0.99]，I = 0%）或严重程度（MD 0.02，95%CI[-0.13，0.17]，I = 0%）没有影响。针灸与 HT 在 E 血清水平（MD 6.56，95%CI[-3.77，16.89]，I = 76%）、FSH（MD 1.06，95%CI[-1.44，3.56]，I = 0%）或 LH（MD-3.36，95%CI[-13.37，6.65]，I = 89%）方面没有差异。
针灸可能不会降低潮热频率，但似乎对血清激素水平有类似的影响，即增加 E2，降低 FSH 和 LH。考虑到纳入的试验数量少且质量低，因此无法得出明确的结论，需要进一步开展高质量的 RCT。
